Cobalt-catalyzed ortho-arylation of aromatic imines with aryl chlorides
Date of Issue2012
School of Physical and Mathematical Sciences
An ortho-arylation reaction of aromatic imines with aryl chlorides has been achieved using a cobalt–N-heterocyclic carbene catalyst in combination with a neopentyl Grignard reagent. The reaction takes place at room temperature to afford biaryl products in moderate to good yields.
© 2012 American Chemical Society.