dc.contributor.authorWong, Bin Sheng
dc.contributor.authorTeoh, Swee-Hin
dc.contributor.authorKang, Lifeng
dc.date.accessioned2013-07-01T06:47:05Z
dc.date.available2013-07-01T06:47:05Z
dc.date.copyright2012en_US
dc.date.issued2012
dc.identifier.citationWong, B. S., Teoh, S.-H., & Kang, L. (2012). Polycaprolactone scaffold as targeted drug delivery system and cell attachment scaffold for postsurgical care of limb salvage. Drug Delivery and Translational Research, 2(4), 272-283.en_US
dc.identifier.issn2190-393Xen_US
dc.identifier.urihttp://hdl.handle.net/10220/10862
dc.description.abstractIn this paper, a dual-function drug-laden polycaprolactone scaffold, which can serve as both targeted drug delivery system and attachment platform for tissue regeneration for the postsurgical care of limb salvage procedure, was developed with a simple and solvent-free molding technique. Scaffolds of varying surface architecture were created using poly(ethylene glycol) diacrylate microneedle arrays. A model drug, rhodamine B, was incorporated homogenously into the scaffold. In vitro drug release studies showed that rhodamine B was released in a slow and sustained manner for 112 days. Its release rate was affected by drug loading and scaffold surface architecture. Release of rhodamine B from the scaffolds followed the Higuchi diffusion model. Other drugs, namely, doxorubicin and lidocaine hydrochloride, were also effectively loaded into and released from the scaffolds. Cell attachment study demonstrated potential for the scaffolds to provide attachment platforms for tissue regeneration.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesDrug delivery and translational researchen_US
dc.rights© 2012 Controlled Release Society.en_US
dc.titlePolycaprolactone scaffold as targeted drug delivery system and cell attachment scaffold for postsurgical care of limb salvageen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s13346-012-0096-9


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