dc.contributor.authorTan, Kelvin Yong Leng
dc.contributor.authorPigeon, Pascal
dc.contributor.authorTop, Siden
dc.contributor.authorLabbé, Eric
dc.contributor.authorBuriez, Olivier
dc.contributor.authorHillard, Elizabeth A.
dc.contributor.authorVessières, Anne
dc.contributor.authorAmatore, Christian
dc.contributor.authorLeong, Weng Kee
dc.contributor.authorJaouen, Gérard
dc.date.accessioned2013-07-01T07:13:45Z
dc.date.available2013-07-01T07:13:45Z
dc.date.copyright2012en_US
dc.date.issued2012
dc.identifier.citationTan, K. Y. L., Pigeon, P., Top, S., Labbé, E., Buriez, O., Hillard, E. A., et al. (2012). Ferrocenyl catechols: synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells. Dalton Transactions, 41(25), 7537-7549.en_US
dc.identifier.issn1477-9226en_US
dc.identifier.urihttp://hdl.handle.net/10220/10868
dc.description.abstractThe synthesis and anti-tumoral properties of a series of compounds possessing a ferrocenyl group tethered to a catechol via a conjugated system is presented. On MDA-MB-231 breast cancer cell lines, the catechol compounds display a similar or greater anti-proliferative potency (IC50 values ranging from 0.48–1.21 μM) than their corresponding phenolic analogues (0.57–12.7 μM), with the highest activity found for species incorporating the [3]ferrocenophane motif. On the electrochemical timescale, phenolic compounds appear to oxidize to the quinone methide, while catechol moieties form the o-quinone by a similar mechanism. Chemical oxidation of selected compounds with Ag2O confirms this interpretation and demonstrates the probable involvement of such oxidative metabolites in the in vitro activity of these species.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesDalton transactionsen_US
dc.rights© 2012 The Royal Society of Chemistry.en_US
dc.titleFerrocenyl catechols : synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cellsen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1039/c2dt30700f


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