dc.contributor.authorTan, Kelvin Yong Leng
dc.contributor.authorPigeon, Pascal
dc.contributor.authorTop, Siden
dc.contributor.authorLabbé, Eric
dc.contributor.authorBuriez, Olivier
dc.contributor.authorHillard, Elizabeth A.
dc.contributor.authorVessières, Anne
dc.contributor.authorAmatore, Christian
dc.contributor.authorLeong, Weng Kee
dc.contributor.authorJaouen, Gérard
dc.identifier.citationTan, K. Y. L., Pigeon, P., Top, S., Labbé, E., Buriez, O., Hillard, E. A., et al. (2012). Ferrocenyl catechols: synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells. Dalton Transactions, 41(25), 7537-7549.en_US
dc.description.abstractThe synthesis and anti-tumoral properties of a series of compounds possessing a ferrocenyl group tethered to a catechol via a conjugated system is presented. On MDA-MB-231 breast cancer cell lines, the catechol compounds display a similar or greater anti-proliferative potency (IC50 values ranging from 0.48–1.21 μM) than their corresponding phenolic analogues (0.57–12.7 μM), with the highest activity found for species incorporating the [3]ferrocenophane motif. On the electrochemical timescale, phenolic compounds appear to oxidize to the quinone methide, while catechol moieties form the o-quinone by a similar mechanism. Chemical oxidation of selected compounds with Ag2O confirms this interpretation and demonstrates the probable involvement of such oxidative metabolites in the in vitro activity of these species.en_US
dc.relation.ispartofseriesDalton transactionsen_US
dc.rights© 2012 The Royal Society of Chemistry.en_US
dc.titleFerrocenyl catechols : synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cellsen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US

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