dc.contributor.authorDong, Jing
dc.contributor.authorBi, Renzhe
dc.contributor.authorHo, Jun Hui
dc.contributor.authorThong, Patricia Soo-Ping
dc.contributor.authorSoo, Khee-Chee
dc.contributor.authorLee, Kijoon
dc.identifier.citationDong, J., Bi, R., Ho, J. H., Thong, P. S. P., Soo, K.-C., & Lee, K. (2012). Diffuse correlation spectroscopy with a fast Fourier transform-based software autocorrelator. Journal of Biomedical Optics, 17(9), 097004-.en_US
dc.description.abstractDiffuse correlation spectroscopy (DCS) is an emerging noninvasive technique that probes the deep tissue blood flow, by using the time-averaged intensity autocorrelation function of the fluctuating diffuse reflectance signal. We present a fast Fourier transform (FFT)-based software autocorrelator that utilizes the graphical programming language LabVIEW (National Instruments) to complete data acquisition, recording, and processing tasks. The validation and evaluation experiments were conducted on an in-house flow phantom, human forearm, and photodynamic therapy (PDT) on mouse tumors under the acquisition rate of ∼400  kHz. The software autocorrelator in general has certain advantages, such as flexibility in raw photon count data preprocessing and low cost. In addition to that, our FFT-based software autocorrelator offers smoother starting and ending plateaus when compared to a hardware correlator, which could directly benefit the fitting results without too much sacrifice in speed. We show that the blood flow index (BFI) obtained by using a software autocorrelator exhibits better linear behavior in a phantom control experiment when compared to a hardware one. The results indicate that an FFT-based software autocorrelator can be an alternative solution to the conventional hardware ones in DCS systems with considerable benefits.en_US
dc.relation.ispartofseriesJournal of biomedical optics.en_US
dc.rights© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). This paper was published in Journal of Biomedical Optics and is made available as an electronic reprint (preprint) with permission of Society of Photo-Optical Instrumentation Engineers (SPIE). The paper can be found at the following official DOI: [http://dx.doi.org/10.1117/1.JBO.17.9.097004]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.en_US
dc.titleDiffuse correlation spectroscopy with a fast Fourier transform-based software autocorrelatoren_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.description.versionPublished versionen_US

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