Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/98965
Title: Numerical investigation of lens based setup for depth sensitive diffuse reflectance measurements in an epithelial cancer model
Authors: Liu, Quan
Zhu, Caigang
Issue Date: 2012
Source: Zhu, C., & Liu, Q. (2012). Numerical investigation of lens based setup for depth sensitive diffuse reflectance measurements in an epithelial cancer model. Optics Express, 20(28), 29807-29822.
Series/Report no.: Optics express
Abstract: Lens based setups have been explored for non-contact diffuse reflectance measurements to reduce the uncertainty due to inconsistent probe-sample pressure in the past years. However, there have been no reports describing the details of Monte Carlo modeling of lens based non-contact setup for depth sensitive diffuse reflectance measurements to the best of our knowledge. In this study, we first presented a flexible Monte Carlo method to model non-contact diffuse reflectance measurements in a lens based setup. Then this method was used to simulate diffuse reflectance measurements from a squamous cell carcinoma (SCC) tissue model in the cone shell, cone and hybrid configurations, in which the cone shell configuration has not been previously proposed in optical spectroscopy. Depth sensitive measurements were achieved by adjusting the following two parameters: (1) the depth of focal point of the imaging lens in the SCC model; and (2) the cone radius in the cone configuration or the ring radius in the cone shell configuration. It was demonstrated that the cone shell and the hybrid configurations in general have better depth sensitivity to the tumor and the stroma than the more commonly used cone configuration for diffuse reflectance measurements in the SCC model.
URI: https://hdl.handle.net/10356/98965
http://hdl.handle.net/10220/10941
ISSN: 1094-4087
DOI: http://dx.doi.org/10.1364/OE.20.029807
Rights: © 2012 Optical Society of America. This paper was published in Optics Express and is made available as an electronic reprint (preprint) with permission of Optical Society of America. The paper can be found at the following official DOI: [http://dx.doi.org/10.1364/OE.20.029807]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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