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Title: Sequencing the transcriptional network of androgen receptor in prostate cancer
Authors: Chng, Kern Rei
Cheung, Edwin
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2012
Source: Chng, K. R., Cheung, E. (2012). Sequencing the transcriptional network of androgen receptor in prostate cancer. Cancer Letters, 340(2), 254-60.
Series/Report no.: Cancer letters
Abstract: The progression of prostate cancer is largely dependent on the activity of the androgen receptor (AR), which in turn, correlates with the net output of the AR transcriptional regulatory network. A detailed and thorough understanding of the AR transcriptional regulatory network is therefore critical in the strategic manipulation of AR activity for the targeted eradication of prostate cancer cells. In this mini-review, we highlight some of the novel and unexpected mechanistic and functional insights of the AR transcriptional network derived from recent targeted sequencing (ChIP–Seq) studies of AR and its coregulatory factors in prostate cancer cells.
Rights: © 2012 Elsevier Ireland Ltd.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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