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Title: RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors
Authors: Chuang, Linda Shyue Huey
Lai, Soak Kuan
Murata-Hori, Maki
Yamada, Ayumi
Li, Hoi-Yeung
Gunaratne, Jayantha
Ito, Yoshiaki
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2012
Source: Chuang, L. S. H., Lai, S. K., Murata-Hori, M., Yamada, A., Li, H.-Y., Gunaratne, J., et al. (2012). RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors. Cell Cycle, 11(10), 1938-1947.
Series/Report no.: Cell cycle
Abstract: RUNX family proteins are critical regulators of lineage differentiation during development. The high prevalence of RUNX mutation/epigenetic inactivation in human cancer indicates a causative role for dysfunctional RUNX in carcinogenesis. This is supported by well-documented evidence of functional interaction of RUNX with components of major oncogenic or tumor suppressive signaling pathways such as TGFβ and Wnt. Here, we explore the binding partners of RUNX3 proteins to further define the scope of RUNX3 function. Using a mass spectrometry-based approach, we found that RUNX3 binds to centrosomal protein rootletin. This led us to uncover the presence of RUNX proteins at the centrosome. Our findings suggest a potential function for RUNX3 during mitosis.
Rights: © 2012 Landes Bioscience.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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