The acid free asymmetric intermolecular α-alkylation of aldehydes in fluorinated alcohols
Date of Issue2012
School of Physical and Mathematical Sciences
The acid free asymmetric intermolecular α-alkylation of aldehydes with alcohols has been discovered using trifluoroethanol as solvent. This unprecedented system affords the enantioenriched functionalized primary alcohols (after NaBH4 reduction) in high yields and good to excellent enantioselectivities with wide substrate scope in the absence of any acid additive.
© 2012 The Royal Society of Chemistry.