dc.contributor.authorThan, Aung
dc.contributor.authorTee, Wei Teng
dc.contributor.authorChen, Peng
dc.date.accessioned2013-07-11T01:58:30Z
dc.date.available2013-07-11T01:58:30Z
dc.date.copyright2012en_US
dc.date.issued2012
dc.identifier.citationThan, A., Tee, W. T., Chen, P. (2012). Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors. Molecular and Cellular Endocrinology, 351(2), 296-305.
dc.identifier.urihttp://hdl.handle.net/10220/11154
dc.description.abstractAdipocytes play pivotal roles in regulating metabolism through secretion of a variety of adipokines, which in turn is regulated by other metabolic factors (e.g., insulin). Understanding the regulations of adipokine secretion is important because adipokines are implicated with metabolic disorders, such as, obesity and diabetes mellitus. Here, we investigated the regulatory roles of angiotensin II (AngII) on the secretion of apelin in 3T3-L1 adipocytes, and distinct signaling pathways mediated by AngII receptor type 1 (AT1) and type 2 (AT2) were revealed. It was found that activation of AT1 receptors stimulates apelin secretion in Ca2+, protein kinase C, and MAPK kinase dependent ways while activation of AT2 receptors inhibits apelin secretion through cAMP and cGMP dependent pathways. Furthermore, we demonstrate that the expression of apelin receptor (APJ) is also similarly regulated by AT1 and AT2 receptors. Finally, a detailed AngII signaling map is proposed.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesMolecular and cellular endocrinologyen_US
dc.rights© 2012 Elsevier Ireland Ltd.en_US
dc.titleApelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptorsen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.mce.2012.01.005


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