Expedient synthesis of highly substituted pyrroles via tandem rearrangement of α-diazo oxime ethers
Chan, Wei Chuen
Date of Issue2012
School of Physical and Mathematical Sciences
An efficient rhodium-catalyzed synthesis of 2H-azirines and pyrroles has been developed. Novel rearrangement of α-oximino ketenes derived from α-diazo oxime ethers provides 2H-azirines bearing quaternary centers and allows for subsequent rearrangement to highly substituted pyrroles in excellent yields.
Journal of the American chemical society
© 2012 American Chemical Society.