Oxidative γ-addition of enals to trifluoromethyl ketones : enantioselectivity control via Lewis acid/N-heterocyclic carbene cooperative catalysis
Chi, Robin Yonggui
Date of Issue2012
School of Physical and Mathematical Sciences
An oxidative γ-functionalization of enals under N-heterocyclic carbene (NHC) catalysis to give unsaturated δ-lactones is disclosed. Enantioselectivity control involving the relatively remote enal γ-carbon was achieved via Lewis acid [Sc(OTf)3 or combined Sc(OTf)3/Mg(OTf)2] and NHC cooperative catalysis.
Journal of the American chemical society
© 2012 American Chemical Society.