C–C bond formation via copper-catalyzed conjugate addition reactions to enones in water at room temperature
Lipshutz, Bruce H.
Leong, Wendy Wen Yi
Isley, Nicholas A.
Date of Issue2012
School of Physical and Mathematical Sciences
Conjugate addition reactions to enones can now be done in water at room temperature with in situ generated organocopper reagents. Mixing an enone, zinc powder, TMEDA, and an alkyl halide in a micellar environemnt containing catalytic amounts of Cu(I), Ag(I), and Au(III) leads to 1,4-adducts in good isolated yields: no organometallic precursor need be formed.
Journal of the American chemical society
© 2012 American Chemical Society.