dc.contributor.authorKhung, Yit-Lung
dc.contributor.authorBastari, Kelsen
dc.contributor.authorCho, Xing Ling
dc.contributor.authorYee, Wu Aik
dc.contributor.authorLoo, Say Chye Joachim
dc.identifier.citationKhung, Y. L., Bastari, K., Cho, X. L., Yee, W. A., & Loo, S. C. J. (2012). Designing calcium phosphate-based bifunctional nanocapsules with bone-targeting properties. Journal of nanoparticle research, 14(6).en_US
dc.description.abstractUsing sodium dodecyl sulphate micelles as template, hollow-cored calcium phosphate nanocapsules were produced. The surfaces of the nanocapsule were subsequently silanised by a polyethylene glycol (PEG)-based silane with an N-hydroxysuccinimide ester end groups which permits for further attachment with bisphosphonates (BP). Characterisations of these nanocapsules were investigated using Field Emission Scanning Electron Microscopy (FESEM), Transmission Electron Microscopy, Fourier Transform Infra-Red Spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy and Dynamic Light Scattering. To further validate the bone-targeting potential, dentine discs were incubated with these functionalised nanocapsules. FESEM analysis showed that these surface-modified nanocapsules would bind strongly to dentine surfaces compared to non-functionalised nanocapsules. We envisage that respective components would give this construct a bifunctional attribute, whereby (1) the shell of the calcium phosphate nanocapsule would serve as biocompatible coating aiding in gradual osteoconduction, while (2) surface BP moieties, acting as targeting ligands, would provide the bone-targeting potential of these calcium phosphate nanocapsules.en_US
dc.relation.ispartofseriesJournal of nanoparticle researchen_US
dc.rights© 2012 Springer Science+Business Media B.V.en_US
dc.titleDesigning calcium phosphate-based bifunctional nanocapsules with bone-targeting propertiesen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Materials Science and Engineeringen_US

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