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|Title:||Synthesis and cytocompatibility of manganese (II) and iron (III) substituted hydroxyapatite nanoparticles||Authors:||Li, Yan
Ooi, Chui Ping
|Keywords:||DRNTU::Engineering::Chemical engineering||Issue Date:||2011||Source:||Li, Y., Widodo, J., Lim, S., & Ooi, C. P. (2012). Synthesis and cytocompatibility of manganese (II) and iron (III) substituted hydroxyapatite nanoparticles. Journal of Materials Science, 47(2), 754-763.||Series/Report no.:||Journal of materials science||Abstract:||Manganese (II) and iron (III) substituted hydroxyapatite (HA, Ca10(PO4)6(OH)2) nanoparticles were synthesized using wet chemical method. All samples were single-phase, non-stoichiometric and B-type carbonated hydroxyapatite. Compared with pure HA, Mn2+ substituted (MnHA) and Fe3+ doped HA (FeHA) did not demonstrate significant structure deviation. Since ion exchange mechanism was applied for the synthesis process, the morphology and particle size were not significantly affected: all samples were elongated spheroids of around 70 nm. The presence of Fe and Mn was confirmed by energy dispersive X-ray spectroscopy (EDX) while the concentrations were quantified by inductively coupled plasma (ICP). Fe3+ ions were more active than Mn2+ ions in replacing Ca2+ ions in HA lattice structure. The magnetic property of HA was modified by substitution with Fe. The Fe5 (Feadded/Caadded = 5% by molar ratio) was paramagnetic while pure HA was diamagnetic. Results of extraction assay from cells cultured in extracted medium for 72 h suggested that both MnHA and FeHA were non-cytotoxic to osteoblast cells. Meanwhile, the presence of Fe3+ ions in HA demonstrated significant positive effect on osteoblast cells, where the cell number on Fe5 pellets was twice that of pure HA and MnHA samples.||URI:||https://hdl.handle.net/10356/96230
|DOI:||http://dx.doi.org/10.1007/s10853-011-5851-7||Rights:||© 2011 Springer Science+Business Media, LLC.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SCBE Journal Articles|
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