dc.contributor.authorHuang, Yinhua
dc.contributor.authorPullarkat, Sumod A.
dc.contributor.authorLi, Yongxin
dc.contributor.authorLeung, Pak-Hing
dc.identifier.citationHuang, Y., Pullarkat, S. A., Li, Y., & Leung, P.-H. (2012). Palladacycle-Catalyzed Asymmetric Hydrophosphination of Enones for Synthesis of C*- and P*-Chiral Tertiary Phosphines. Inorganic Chemistry, 51(4), 2533-2540.en_US
dc.description.abstractA highly reactive and stereoselective hydrophosphination of enones catalyzed by palladacycles for the synthesis of C*- and P*-chiral tertiary phosphines has been developed. When Ph2PH was employed as the hydrophosphinating reagent, a series of C*-chiral tertiary phosphines were synthesized (C*–P bond formation) in high yields with excellent enantioselectivities, and a single recrystallization provides access to their enantiomerically pure forms. When racemic secondary phosphines rac-R3(R4)PH were utilized, a series of tertiary phosphines containing both C*- and P*-chiral centers were generated (C*–P* bond formation) in high yields with good diastereo- and enantioselectivities. The stereoelectronic factors involved in the catalytic cycle have been revealed.en_US
dc.relation.ispartofseriesInorganic chemistryen_US
dc.rights© 2012 American Chemical Society.en_US
dc.titlePalladacycle-catalyzed asymmetric hydrophosphination of enones for synthesis of C*- and P*-chiral tertiary phosphinesen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US

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