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Title: Stem cell genome-to-systems biology
Authors: Chia, Na Yu
Ng, Huck-Hui
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2011
Source: Chia, N. Y., & Ng, H.-H. (2012). Stem cell genome-to-systems biology. Wiley interdisciplinary reviews : systems biology and medicine, 4(1), 39-49.
Series/Report no.: Wiley interdisciplinary reviews : systems biology and medicine
Abstract: Stem cells are capable of extended proliferation and concomitantly differentiating into a plethora of specialized cell types that render them apropos for their usage as a form of regenerative medicine for cell replacement therapies. The molecular processes that underlie the ability for stem cells to self-renew and differentiate have been intriguing, and elucidating the intricacies within the genome is pertinent to enhance our understanding of stem cells. Systems biology is emerging as a crucial field in the study of the sophisticated nature of stem cells, through the adoption of multidisciplinary approaches which couple high-throughput experimental techniques with computational and mathematical analysis. This allows for the determination of the molecular constituents that govern stem cell characteristics and conjointly with functional validations via genetic perturbation and protein location binding analysis necessitate the construction of the complex transcriptional regulatory network. With the elucidation of protein–protein interaction, protein–DNA regulation, microRNA involvement as well as the epigenetic modifications, it is possible to comprehend the defining features of stem cells at the system level.
ISSN: 1939-005X
DOI: 10.1002/wsbm.151
Rights: © 2011 Wiley Periodicals, Inc.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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