Catalytic enantioselective conjugate addition of grignard reagents to cyclic enones using C 1 -1,1′-bisisoquinoline-based chiral ligands
Judeh, Zaher M. A.
Date of Issue2012
School of Chemical and Biomedical Engineering
New highly constrained chiral C1-1,10-bisisoquinoline ligands were examined in the enantioselective conjugate addition of Grignard reagents to cyclohexenone and cyclopentenone. The desired 1,4-adducts were obtained in excellent yield and moderate enantiomeric excess (up to 35%).
Synthetic communications: an international journal for rapid communication of synthetic organic chemistry
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