Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/95768
Title: Beta atomic contacts : identifying critical specific contacts in protein binding interfaces
Authors: Liu, Qian
Kwoh, Chee Keong
Hoi, Steven Chu Hong
Keywords: DRNTU::Engineering::Computer science and engineering
Issue Date: 2013
Source: Liu, Q., Kwoh, C. K., & Hoi, S. C. H. (2013). Beta Atomic Contacts: Identifying Critical Specific Contacts in Protein Binding Interfaces. PLoS ONE, 8(4), e59737.
Series/Report no.: PLoS ONE
Abstract: Specific binding between proteins plays a crucial role in molecular functions and biological processes. Protein binding interfaces and their atomic contacts are typically defined by simple criteria, such as distance-based definitions that only use some threshold of spatial distance in previous studies. These definitions neglect the nearby atomic organization of contact atoms, and thus detect predominant contacts which are interrupted by other atoms. It is questionable whether such kinds of interrupted contacts are as important as other contacts in protein binding. To tackle this challenge, we propose a new definition called beta (β) atomic contacts. Our definition, founded on the β-skeletons in computational geometry, requires that there is no other atom in the contact spheres defined by two contact atoms; this sphere is similar to the van der Waals spheres of atoms. The statistical analysis on a large dataset shows that β contacts are only a small fraction of conventional distance-based contacts. To empirically quantify the importance of β contacts, we design βACV, an SVM classifier with β contacts as input, to classify homodimers from crystal packing. We found that our βACV is able to achieve the state-of-the-art classification performance superior to SVM classifiers with distance-based contacts as input. Our βACV also outperforms several existing methods when being evaluated on several datasets in previous works. The promising empirical performance suggests that β contacts can truly identify critical specific contacts in protein binding interfaces. β contacts thus provide a new model for more precise description of atomic organization in protein quaternary structures than distance-based contacts.
URI: https://hdl.handle.net/10356/95768
http://hdl.handle.net/10220/11932
ISSN: 1932-6203
DOI: http://dx.doi.org/10.1371/journal.pone.0059737
Rights: © 2013 The Authors. This paper was published in PLoS ONE and is made available as an electronic reprint (preprint) with permission of The Authors. The paper can be found at the following official DOI: [http://dx.doi.org/10.1371/journal.pone.0059737]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCSE Journal Articles

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