Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/95871
Title: Identification and characterization of mesenchymal stem cells derived from the trabecular meshwork of the human eye
Authors: Tay, Cheryl Y.
Chu, Stephanie W. L.
Stanton, Lawrence W.
Wong, Tina T.
Sathiyanathan, Padmapriya
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2012
Source: Tay, C. Y., Sathiyanathan, P., Chu, S. W. L., Stanton, L. W., & Wong, T. T. (2012). Identification and Characterization of Mesenchymal Stem Cells Derived from the Trabecular Meshwork of the Human Eye. Stem Cells and Development, 21(9), 1381-1390.
Series/Report no.: Stem cells and development
Abstract: Mesenchymal stem cells (MSC) have been isolated from several adult human tissues. Their propensity to differentiate into cell types of connective tissue, such as osteocytes, chondrocytes, and adipocytes, suggests that MSC may function as a reserve of progenitor cells that repair and maintain healthy adult tissues. Dysfunction of the trabecular meshwork (TM), a connective tissue at the anterior region of the human eye that regulates intraocular pressure, plays a major role in the pathogenesis of glaucoma. The mechanobiology and pharmacological aspects of the TM tissue have been relatively well studied in disease states. Less well understood is if there are progenitor cells within the TM that contribute to maintenance of this tissue. In this study, we have identified and characterized an expandable population of cells that have stem cell-like properties. In particular, these cells express the markers CD73, CD90, and CD105, which are typically associated with MSC. Thus, we have named these cells TM-MSC. As further evidence that these cells are MSC, they were differentiated in vitro into adipocytes, osteocytes, and chondrocytes. Through genomic characterization, we show that TM-MSC have gene expression patterns most similar to MSC derived from other tissues. TM-MSC express genes found on adult TM tissue, suggesting that TM-MSC are progenitor cells that serve to maintain a healthy TM.
URI: https://hdl.handle.net/10356/95871
http://hdl.handle.net/10220/11992
DOI: http://dx.doi.org/10.1089/scd.2011.0655
Rights: © 2012 Mary Ann Liebert, Inc. This paper was published in Stem Cells and Development and is made available as an electronic reprint (preprint) with permission of Mary Ann Liebert, Inc. The paper can be found at the following official DOI: [http://dx.doi.org/10.1089/scd.2011.0655]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
metadata.item.grantfulltext: open
metadata.item.fulltext: With Fulltext
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