Iron-oxide nanoparticles mediated cyclization of 3-(4-chlorophenyl)-1-hydrazinylisoquinoline to 1-(4,5-dihydropyrazol-1-yl)isoquinolines
Nawaz Khan, F.
Jin, Jong Sung
Jeong, Euh Duck
Kim, Hyun Gyu
Date of Issue2012
School of Chemical and Biomedical Engineering
Iron-oxide nanoparticles were obtained using chitosan templates and their crystalline character and particle size have been confirmed through powder x-ray diffraction and transmission electron microscopy measurements. The particle sizes were found to be 10–25 nm. The diversified chalcones 2 were reacted with 1-hydrazinylisoquinoline 1 in the presence of iron-oxide nanoparticles to the corresponding pyrazolines 3a–j in high yield and purity. The pyrazolines were characterized by spectroscopic techniques.
Research on chemical intermediates
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