Fast reconstruction of Raman spectra from narrow-band measurements based on Wiener estimation
Ong, Yi Hong
Date of Issue2012
Optics in Health Care and Biomedical Optics (5th : 2012 : Beijing, China)
School of Chemical and Biomedical Engineering
Raman spectroscopy has demonstrated great potential in the study of biological molecules in a variety of biomedical applications. But slow data acquisition due to weak Raman signals from these molecules has prevented its wide use especially in an imaging setup. We propose a novel method to reconstruct the entire Raman spectrum from a few narrow-band measurements based on Wiener estimation. This method has been tested on Raman spectra from individual cells and shown fast speed and excellent accuracy. This method represents a new direction to speed up Raman data acquisition in an imaging setup to investigate fast changing phenomena.
© 2012 SPIE. This paper was published in Proceedings of SPIE - Optics in Health Care and Biomedical Optics V and is made available as an electronic reprint (preprint) with permission of SPIE. The paper can be found at the following official DOI: [http://dx.doi.org/10.1117/12.999473]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.