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|Title:||Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium||Authors:||Ilies, Laurean
|Issue Date:||2012||Source:||Ilies, L., Kobayashi, M., Matsumoto, A., Yoshikai, N., & Nakamura, E. (2012). Iron-Catalyzed Nitrogen-Directed Coupling of Arene and Aryl Bromides Mediated by Metallic Magnesium. Advanced Synthesis & Catalysis, 354(4), 593-596.||Series/Report no.:||Advanced synthesis & catalysis||Abstract:||2-Arylpyridines, 2-alkenylpyridine, and aromatic imines can be coupled with aryl bromides in the presence of an iron catalyst, metallic magnesium, a diamine ligand and an organic dihalide oxidant at 0 °C. The use of a 1:1 mixture of tetrahydrofuran and 1,4-dioxane is essential for this CH bond activation reaction. The reaction has wider scope of the substrate compared with the reaction using a separately prepared Grignard reagent, and proceeds with lower catalyst loading (2.5 mol%).||URI:||https://hdl.handle.net/10356/98283
|ISSN:||1615-4150||DOI:||http://dx.doi.org/10.1002/adsc.201100791||Rights:||© 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SPMS Journal Articles|
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