Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/98283
Title: Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium
Authors: Ilies, Laurean
Kobayashi, Motoaki
Matsumoto, Arimasa
Yoshikai, Naohiko
Nakamura, Eiichi
Issue Date: 2012
Source: Ilies, L., Kobayashi, M., Matsumoto, A., Yoshikai, N., & Nakamura, E. (2012). Iron-Catalyzed Nitrogen-Directed Coupling of Arene and Aryl Bromides Mediated by Metallic Magnesium. Advanced Synthesis & Catalysis, 354(4), 593-596.
Series/Report no.: Advanced synthesis & catalysis
Abstract: 2-Arylpyridines, 2-alkenylpyridine, and aromatic imines can be coupled with aryl bromides in the presence of an iron catalyst, metallic magnesium, a diamine ligand and an organic dihalide oxidant at 0 °C. The use of a 1:1 mixture of tetrahydrofuran and 1,4-dioxane is essential for this CH bond activation reaction. The reaction has wider scope of the substrate compared with the reaction using a separately prepared Grignard reagent, and proceeds with lower catalyst loading (2.5 mol%).
URI: https://hdl.handle.net/10356/98283
http://hdl.handle.net/10220/12334
ISSN: 1615-4150
DOI: http://dx.doi.org/10.1002/adsc.201100791
Rights: © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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