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      Advanced immobilization and amplification for high performance protein chips

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      Author
      Liu, Yingshuai
      Li, Chang Ming
      Date of Issue
      2012
      School
      School of Chemical and Biomedical Engineering
      Research Centre
      Centre for Advanced Bionanosystems
      Abstract
      With the success of high-throughput DNA microarrays, protein biochips have been intensively investigated and broadly used in bioscience research, clinic diagnosis, drug discovery, and other applications. However, there is great need to significantly improve the sensitivity of protein chips, especially in early diagnosis. A major challenge of improving sensitivity is that protein detection does not have an effective amplification method, such as PCR for DNA microarrays. Construction of unique biofilms for efficient immobilization of protein probes and innovation of new amplification schemes could play a critical role in performance improvement of protein biochips. With dramatic developments in microfabrication, nanotechnologies, and biotechnologies, enormous progress has been made, particularly in improving biosensing sensitivity. This article reviews new advances in protein biochip technologies with emphasis on novel approaches for efficient probe immobilization and nanomaterials-assisted signal amplification for high performance protein chips. Prominent progress in integration of protein microarrays with microfluidic platforms is briefly discussed. The major challenges and perspectives on the future of protein biochips are also addressed.
      Type
      Journal Article
      Series/Journal Title
      Analytical letters
      Rights
      © 2012 Taylor & Francis Group, LLC.
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      • SCBE Journal Articles
      http://dx.doi.org/10.1080/00032719.2011.633187
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