Catalytic asymmetric [4+2] annulation initiated by an Aza-Rauhut-Currier reaction : facile entry to highly functionalized tetrahydropyridines
Date of Issue2012
School of Physical and Mathematical Sciences
Under control: The first example of chiral amino phosphine catalysts for the title reaction between vinyl ketones and N-sulfonyl-1-aza-1,3-dienes has been developed. Under ambient conditions, this protocol provides straightforward access to densely functionalized, enantioenriched tetrahydropyridines with high levels of sterecontrol in good to excellent yields.
Angewandte chemie international edition
© 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.