Nano-optofluidics for single molecule detection and sorting.
Tsai, J. M.
Kwong, Dim Lee.
Liu, A. Q.
Date of Issue2012
IEEE International Conference on Micro Electro Mechanical Systems (25th : 2012 : Paris, France)
School of Electrical and Electronic Engineering
This paper reports a nano-optofluidic device using evanescent wave sensing for single molecule detection and sorting based on hydrodynamic focusing and total internal reflection (TIR). Nano-sized samples in liquid can be measured and counted even their size is smaller than the diffraction limit. We demonstrated 200-nm nanoparticle detecting which is beyond the diffraction limit. As compared to the conventional TIR microscopy, the nano-optofluidic device can measure and count all samples in real time. It has wide range applications in the single molecule detection, imaging and counting.
DRNTU::Engineering::Electrical and electronic engineering
© 2012 IEEE.