N-heterocyclic carbene catalyzed homoenolate-addition reaction of enals and nitroalkenes : asymmetric synthesis of 5-carbon-synthon δ-nitroesters
Date of Issue2012
School of Physical and Mathematical Sciences
Synthesizing synthons: The highly enantioselective title reaction is described. It employs catalytic amounts of N-heterocyclic carbene precursors and transforms a broad range of nitroalkenes, such as nitrodienes, nitroenynes, and nitrostyrenes, through reaction with a broad range of enals, into δ-nitroesters via homoenolate intermediates (see scheme).
Angewandte chemie international edition
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