Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/98862
Title: Deactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of rats
Authors: Temel, Yasin.
Blokland, Arjan.
Lim, Lee Wei.
Issue Date: 2012
Source: Temel, Y., Blokland, A.,& Lim, L. W. (2012). Deactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of rats. Behavioural Brain Research, 233(2), 322-325.
Series/Report no.: Behavioural brain research
Abstract: The majority of patients with panic disorder express a fearful sensation when encountered with panic-related cues. A subpopulation of GABAergic interneurons in the hippocampus has been demonstrated in the regulation of behavioural learning, especially during the contextual fear-conditioning. Here, we examined the influence of panic/fear response induced by deep brain stimulation (DBS) of the periaqueductal gray on these hippocampal parvalbumin-positive interneurons. We found that fear-like behaviour did not change the number of c-Fos immunoreactive and parvalbumin-positive cells. However, a remarkable decrease of c-Fos and parvalbumin co-localization was shown in the hippocampal regions when compared to non-stimulated sham animals. In line with previous studies, our results support the hypothesis that GABAergic regulation resulted in enhanced behavioural reactivity to fear conditioning. In conclusion, our findings indicate that the inhibition of this subpopulation of hippocampal parvalbumin-positive interneurons induced a long lasting anxiety- or fear-like behaviour.
URI: https://hdl.handle.net/10356/98862
http://hdl.handle.net/10220/12666
ISSN: 0166-4328
DOI: http://dx.doi.org/10.1016/j.bbr.2012.05.029
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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