C2-Alkylation of N-pyrimidylindole with vinylsilane via cobalt-catalyzed C–H bond activation
Date of Issue2012
School of Physical and Mathematical Sciences
Direct C2-alkylation of an indole bearing a readily removable N-pyrimidyl group with a vinylsilane was achieved by using a cobalt catalyst generated in situ from CoBr2, bathocuproine, and cyclohexylmagnesium bromide. The reaction allows coupling between a series of N-pyrimidylindoles and vinylsilanes at a mild reaction temperature of 60 °C, affording the corresponding alkylated indoles in moderate to good yields.
Beilstein journal of organic chemistry
© 2012 The Authors. This paper was published in Beilstein Journal of Organic Chemistry and is made available as an electronic reprint (preprint) with permission of Beilstein-Institut. The paper can be found at the following official DOI: [http://dx.doi.org/ 10.3762/bjoc.8.174]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.