Observation of backbone self-crossings of organismal DNAs through atomic force microscopy
Date of Issue2012
School of Physical and Mathematical Sciences
It is demonstrated in our studies that intrinsic curvatures of organismal DNAs could lead to the generation of duplex backbone self-crossings in their relaxed forms. In addition, the backbone self-crossings of the organismal DNAs could be readily confirmed through atomic force microscopic examination.
Bioorganic & medicinal chemistry letters