Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/99097
Title: Mitosis-targeted anti-cancer therapies : where they stand
Authors: Chan, K.-S.
Li, H.-Y.
Koh, Cheng Gee.
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2012
Source: Chan, K. S., Koh, C. G., & Li, H. Y. (2012). Mitosis-targeted anti-cancer therapies: where they stand. Cell death and disease, 3(10).
Series/Report no.: Cell death and disease
Abstract: The strategy of clinically targeting cancerous cells at their most vulnerable state during mitosis has instigated numerous studies into the mitotic cell death (MCD) pathway. As the hallmark of cancer revolves around cell-cycle deregulation, it is not surprising that antimitotic therapies are effective against the abnormal proliferation of transformed cells. Moreover, these antimitotic drugs are also highly selective and sensitive. Despite the robust rate of discovery and the development of mitosis-selective inhibitors, the unpredictable complexities of the human body’s response to these drugs still herald the biggest challenge towards clinical success. Undoubtedly, the need to bridge the gap between promising preclinical trials and effective translational bedside treatment prompts further investigations towards mapping out the mechanistic pathways of MCD, understanding how these drugs work as medicine in the body and more comprehensive target validations. In this review, current antimitotic agents are summarized with particular emphasis on the evaluation of their clinical efficacy as well as their limitations. In addition, we discuss the basis behind the lack of activity of these inhibitors in human trials and the potential and future directions of mitotic anticancer strategies.
URI: https://hdl.handle.net/10356/99097
http://hdl.handle.net/10220/12878
ISSN: 2041-4889
DOI: http://dx.doi.org/10.1038/cddis.2012.148
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

Google ScholarTM

Check

Altmetric

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.