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|Title:||Core structure-based design of Organocatalytic [3+2]-Cycloaddition reactions: highly efficient and Stereocontrolled Syntheses of 3,3′-Pyrrolidonyl Spirooxindoles||Authors:||Barbas III, Carlos F.
Leong, Wendy Wen Yi
|Issue Date:||2012||Source:||Tan, B., Zeng, X., Leong, W. W. Y., Shi, Z., Barbas, C. F.,& Zhong, G. (2012). Core Structure-Based Design of Organocatalytic [3+2]-Cycloaddition Reactions: Highly Efficient and Stereocontrolled Syntheses of 3,3′-Pyrrolidonyl Spirooxindoles. Chemistry - A European Journal, 18(1), 63-67.||Series/Report no.:||Chemistry - a European journal||Abstract:||Extraordinary levels of stereocontrol were achieved in an efficient organocatalytic asymmetric [3+2]-cycloaddition reaction between an α-isothiocyanato imide and various methyleneindolinones. Simple precursors were used for the rapid construction of spirocyclic oxindole derivatives with high enantiopurity and structural diversity, thus providing a new avenue of significance to medicinal chemistry and diversity-oriented synthesis.||URI:||https://hdl.handle.net/10356/99531
|ISSN:||0947-6539||DOI:||10.1002/chem.201103449||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SPMS Journal Articles|
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