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Title: Core structure-based design of Organocatalytic [3+2]-Cycloaddition reactions: highly efficient and Stereocontrolled Syntheses of 3,3′-Pyrrolidonyl Spirooxindoles
Authors: Barbas III, Carlos F.
Tan, Bin
Zeng, Xiaofei
Leong, Wendy Wen Yi
Shi, Zugui
Zhong, Guofu
Issue Date: 2012
Source: Tan, B., Zeng, X., Leong, W. W. Y., Shi, Z., Barbas, C. F.,& Zhong, G. (2012). Core Structure-Based Design of Organocatalytic [3+2]-Cycloaddition Reactions: Highly Efficient and Stereocontrolled Syntheses of 3,3′-Pyrrolidonyl Spirooxindoles. Chemistry - A European Journal, 18(1), 63-67.
Series/Report no.: Chemistry - a European journal
Abstract: Extraordinary levels of stereocontrol were achieved in an efficient organocatalytic asymmetric [3+2]-cycloaddition reaction between an α-isothiocyanato imide and various methyleneindolinones. Simple precursors were used for the rapid construction of spirocyclic oxindole derivatives with high enantiopurity and structural diversity, thus providing a new avenue of significance to medicinal chemistry and diversity-oriented synthesis.
ISSN: 0947-6539
DOI: 10.1002/chem.201103449
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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