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|Title:||Palladium-catalyzed cross-coupling of unactivated alkenes with Acrylates: application to the synthesis of the C13-C21 fragment of Palmerolide A||Authors:||Wen, Zhen-Kang
|Issue Date:||2012||Source:||Wen, Z. K., Xu, Y. H.,& Loh, T. P. (2012). Palladium-Catalyzed Cross-Coupling of Unactivated Alkenes with Acrylates: Application to the Synthesis of the C13-C21 Fragment of Palmerolide A. Chemistry - A European Journal, 18(42), 13284-13287.||Series/Report no.:||Chemistry - a European journal||Abstract:||Diene to meet: A palladium-catalyzed cross-coupling reaction between alkyl-substituted olefins and acrylates gives the corresponding butadienes in moderate yield and stereoselectivity. This atom-economical reaction, which forms Cmath image–Cmath image bonds, tolerates a wide range of allylic and homoallylic alcohols, and acrylates (see scheme; TIPS =triisopropylsilyl). The methodology was applied to the synthesis of the C13–C21 fragment of palmerolide A.||URI:||https://hdl.handle.net/10356/99508
|Appears in Collections:||SPMS Journal Articles|
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