Palladium-catalyzed cross-coupling of unactivated alkenes with Acrylates: application to the synthesis of the C13-C21 fragment of Palmerolide A
Date of Issue2012
School of Physical and Mathematical Sciences
Diene to meet: A palladium-catalyzed cross-coupling reaction between alkyl-substituted olefins and acrylates gives the corresponding butadienes in moderate yield and stereoselectivity. This atom-economical reaction, which forms Cmath image–Cmath image bonds, tolerates a wide range of allylic and homoallylic alcohols, and acrylates (see scheme; TIPS =triisopropylsilyl). The methodology was applied to the synthesis of the C13–C21 fragment of palmerolide A.
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