Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/99426
Title: Silver triflate catalyzed tandem heterocyclization/alkynylation of 1-((2-tosylamino)aryl)but-2-yne-1,4-diols to 2-alkynyl indoles
Authors: Mothe, Srinivasa Reddy
Kothandaraman, Prasath
Lauw, Sherman Jun Liang
Chin, Samuel Ming Wei
Chan, Philip Wai Hong
Issue Date: 2012
Source: Mothe, S. R., Kothandaraman, P., Lauw, S. J. L., Chin, S. M. W.,& Chan, P. W. H. (2012). Silver Triflate Catalyzed Tandem Heterocyclization/Alkynylation of 1-((2-Tosylamino)aryl)but-2-yne-1,4-diols to 2-Alkynyl Indoles. Chemistry - A European Journal, 18(20), 6133-6137.
Series/Report no.: Chemistry - a European journal
Abstract: Don't cross me! 2-Alkynyl indoles were prepared efficiently by the AgOTf-catalyzed tandem heterocyclization/alkynylation of 1-(2-tosylamino)aryl)but-2-yne-1,4-diols under mild conditions (see scheme). The attractiveness of this approach lies in the fact that both the indole ring and alkyne side chain of the N-heterocycle are sequentially formed from low cost, readily available, and ecologically benign starting materials. It also provides the first route to this synthetically valuable class of compounds that is not based on a cross-coupling strategy.
URI: https://hdl.handle.net/10356/99426
http://hdl.handle.net/10220/12940
ISSN: 0947-6539
DOI: http://dx.doi.org/10.1002/chem.201200578
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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