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Title: Cefalexin-immobilized multi-walled carbon nanotubes show strong antimicrobial and anti-adhesion properties
Authors: Qi, Xiaobao
Gunawan, Poernomo
Xu, Rong
Chang, Matthew Wook
Issue Date: 2012
Source: Qi, X., Gunawan, P., Xu, R.,& Chang, M. W. (2012). Cefalexin-immobilized multi-walled carbon nanotubes show strong antimicrobial and anti-adhesion properties. Chemical Engineering Science, 84, 552-556.
Series/Report no.: Chemical engineering science
Abstract: Multi-walled carbon nanotubes (MWNTs) possess weak antimicrobial property. In this report, we demonstrate that the covalent immobilization of the antibiotic cefalexin via poly(ethylene glycol) as a linking agent improves the antimicrobial and anti-adhesive properties of MWNTs against both Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis). In particular, the MWNT-cefalexin composite showed 2-fold higher antimicrobial property than pristine MWNTs against S. aureus and B. subtilis. Moreover, the MWNT-cefalexin deposited film effectively inhibited cell adhesion. Given the simple, inexpensive procedures of our synthesis method, the MWNT-cefalexin composite has the potential to be used as an effective and economical antibacterial and anti-adhesion material for environmental and biomedical applications.
ISSN: 0009-2509
DOI: 10.1016/j.ces.2012.08.054
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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