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Title: Fabrication and characterization of electrospun nano to microfiber made of poly(L-lactide-co-ε-caprolactone)
Authors: Lin, Genevieve
Song, Sin Nee
Wong, Yee Shan
Tan, Lay Poh
Yong, Kim Yeow
Jasmen, Juliana
Dong, Jian Xiang
Issue Date: 2012
Source: Lin, G., Song, S. N., Wong, Y. S., Tan, L. P., Yong, K. Y., Jasmen, J., & Dong, J. X. (2012). Fabrication and Characterization of Electrospun Nano to Microfiber Made of Poly(L-Lactide-co-ε-Caprolactone). Solid State Phenomena, 185, 122-125.
Series/Report no.: Solid state phenomena
Abstract: This project aims to optimize the process parameters for fabricating Poly (L-Lactide-co-ε-Caprolactone) (PLCL) electrospun scaffolds to achieve fiber diameters within the ranges of ~500nm, 500nm~1µm and 1~3µm. Electronspun PLCL solutions of different concentrations (4wt% - 12wt%) were prepared using chloroform and dimethylformamide as solvents. The driving voltage and flow rate were varied from 10kV-30kV and 1ml/hr12ml/hr respectively while the gap distance was kept constant at 15cm. The effects of polymer concentration and process parameters on the properties of the scaffolds fabricated such as Youngs modulus, degree of crystallization and porosity were studied. Scanning electron microscopy (SEM) was used to check the structural integrity (absence of beading and uniform diameter) of the fibers. An increase in polymer concentration resulted in an increase in fiber diameter. Flow rate also showed a positive correlation with fiber diameter. Results showed that Youngs modulus decreased with increasing fiber diameter. Porosity of 76% to 94% was achieved. The potential application of PLCL electrospun scaffolds in the tissue engineering of soft tissues was discussed.
DOI: 10.4028/
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:MSE Journal Articles

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