Identifying DNA motifs based on match and mismatch alignment information
Shu, Jian Jun
Yong, Kian Yan
Date of Issue2013
School of Mechanical and Aerospace Engineering
The conventional way of identifying DNA motifs, solely based on match alignment information, is susceptible to a high number of spurious sites. A novel scoring system has been introduced by taking both match and mismatch alignment information into account. The mismatch alignment information is useful to remove spurious sites encountered in DNA motif searching. As an example, a correct TATA box site in Homo sapiensH4/g gene has successfully been identified based on match and mismatch alignment information.
Journal of mathematical chemistry
© 2013 Springer Science+Business Media New York. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Mathematical Chemistry, Springer Science+Business Media New York. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1007/s10910-013-0175-2].