Mutations I117V and I117M and Oseltamivir sensitivity of pandemic (H1N1) 2009 viruses
Barr, Ian G.
Date of Issue2012
School of Biological Sciences
Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M mutation does not alter oseltamivir sensitivity.
Emerging infectious diseases
© 2012 Public Domain. This paper was published in Emerging Infectious Diseases and is made available as an electronic reprint (preprint) with permission of Public Domain. The paper can be found at the following official DOI: [http://dx.doi.org/10.3201/eid1801.111079]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.