Lab-in-fiber platform for plasmonic photothermal study
Ng, Wei Long
Chan, Chi Chiu
Date of Issue2013
Microfluidics, BioMEMS, and Medical Microsystems (11th : 2013 : San Francisco, USA)
School of Chemical and Biomedical Engineering
Singapore Institute of Manufacturing Technology
A lab-in-fiber platform, comprising a photonic crystal fiber component for light-sample interaction, was experimentally demonstrated to be effective as a sensor and micro-reactor. Specifically, it enabled the discrimination between free and liposome-encapsulated fluorophores as well as allowed for the excitation of in-fiber plasmonic photothermal effects, by alternating between different fiber-coupled inputs. The significant increase in fluorescence emissions upon release of fluorophores, encapsulated within liposomes at self-quenching concentrations, was perceived as a shoulder in the device’s spectral output that otherwise only comprises the input excitation. Markedly, the observed shoulder was only discernible when the photonic crystal fiber was placed in a bent orientation. This was explained to be associated with the bending-induced refractive index profile changes in the fiber cross section that led to increased amounts of evanescent fields for light-sample interactions. Results highlighted the viability of the lab-in-fiber platform as an alternative to current lab-on-a-chip devices.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE). This paper was published in Proceeding of SPIE, Microfluidics, BioMEMS, and Medical Microsystems XI and is made available as an electronic reprint (preprint) with permission of SPIE. The paper can be found at the following official DOI: [http://dx.doi.org/10.1117/12.2003335]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.