Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/99846
Title: Synthesis and antiproliferative activity of helonioside A, 3′,4′,6′-tri-O-feruloylsucrose, lapathoside C and their analogs
Authors: Panda, Parthasarathi
Appalashetti, Manjuvani
Natarajan, Meenubharathi
Mary, Chan-Park
Venkatraman, Subbu S.
Judeh, Zaher M. A.
Keywords: DRNTU::Engineering::Chemical engineering
DRNTU::Engineering::Materials
Issue Date: 2012
Source: Panda, P., Appalashetti, M., Natarajan, M., Mary, C. P., Venkatraman, S. S., & Judeh, Z. M. A. (2012). Synthesis and antiproliferative activity of helonioside A, 3′,4′,6′-tri-O-feruloylsucrose, lapathoside C and their analogs. European journal of medicinal chemistry, 58, 418-430.
Series/Report no.: European journal of medicinal chemistry
Abstract: The first total synthesis of natural phenylpropanoid sucrose esters (PSEs) helonioside A 1, 3′,4′,6′-tri-O-feruloylsucrose 2 and lapathoside C 3 along with 17 unnatural PSE analogs has been successfully accomplished in a short and simple synthetic route. A selected set of 17 synthesized PSEs were evaluated for the antiproliferative activity against human cervical epithelioid carcinoma (HeLa) cell lines using MTS assay method. Eleven (11) compounds showed significant antiproliferative activity with their IC50values ranging from 0.16 to 6.01 μM. The structure–activity-relationship studies revealed that the antiproliferative activity is influenced by the lipophilicity and number of feruloyl substituents on these compounds. The preliminary screening indicated that these compounds are potentially very valuable source for new lead chemotherapeutics.
URI: https://hdl.handle.net/10356/99846
http://hdl.handle.net/10220/13751
DOI: 10.1016/j.ejmech.2012.10.034
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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