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|Title:||Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice||Authors:||Chimote, Geetanjali
Aditya, N. P.
|Keywords:||DRNTU::Science::Biological sciences||Issue Date:||2012||Source:||Aditya, N. P., Chimote, G., Gunalan, K., Banerjee, R., Patankar, S., & Madhusudhan, B. (2012). Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice. Experimental parasitology, 131(3), 292-299.||Series/Report no.:||Experimental parasitology||Abstract:||Curcuminoids are poorly water-soluble compounds with promising antimalarial activity. To overcome some of the drawbacks of curcuminoids, we explored the potential of liposomes for the intravenous delivery of curcuminoids in a model of mouse malaria. The curcuminoids-loaded liposomes were formulated from phosphatidylcholine (soy PC) by the thin-film hydration method. Antimalarial activity of curcuminoids-loaded liposomes alone and in combination with α/β arteether when administered intravenously, was evaluated in Plasmodium berghei infected mice. Animals treated with curcuminoids-loaded liposomes showed lower parasitemia and higher survival when compared to control group (no treatment). Importantly, the combination therapy of curcuminoids-loaded liposomes (40 mg/kg body wt) along with α/β arteether (30 mg/kg body wt) was able to not only cure infected mice but also prevented recrudescence. These data suggest that curcuminoids-loaded liposomes may show promise as a formulation for anti-malarial therapy.||URI:||https://hdl.handle.net/10356/99825
|DOI:||http://dx.doi.org/10.1016/j.exppara.2012.04.010||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SBS Journal Articles|
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