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Title: Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice
Authors: Chimote, Geetanjali
Gunalan, Karthigayan
Patankar, Swati
Banerjee, Rinti
Madhusudhan, Basavaraj
Aditya, N. P.
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2012
Source: Aditya, N. P., Chimote, G., Gunalan, K., Banerjee, R., Patankar, S., & Madhusudhan, B. (2012). Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice. Experimental parasitology, 131(3), 292-299.
Series/Report no.: Experimental parasitology
Abstract: Curcuminoids are poorly water-soluble compounds with promising antimalarial activity. To overcome some of the drawbacks of curcuminoids, we explored the potential of liposomes for the intravenous delivery of curcuminoids in a model of mouse malaria. The curcuminoids-loaded liposomes were formulated from phosphatidylcholine (soy PC) by the thin-film hydration method. Antimalarial activity of curcuminoids-loaded liposomes alone and in combination with α/β arteether when administered intravenously, was evaluated in Plasmodium berghei infected mice. Animals treated with curcuminoids-loaded liposomes showed lower parasitemia and higher survival when compared to control group (no treatment). Importantly, the combination therapy of curcuminoids-loaded liposomes (40 mg/kg body wt) along with α/β arteether (30 mg/kg body wt) was able to not only cure infected mice but also prevented recrudescence. These data suggest that curcuminoids-loaded liposomes may show promise as a formulation for anti-malarial therapy.
DOI: 10.1016/j.exppara.2012.04.010
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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