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|Title:||Characterizing the neurite outgrowth inhibitory effect of Mani||Authors:||Mishra, Manisha
Lin, Michelle K.
|Keywords:||DRNTU::Science::Biological sciences||Issue Date:||2012||Source:||Mishra, M., Lee, S., Lin, M. K., Yamashita, T., & Heese, K. (2012). Characterizing the neurite outgrowth inhibitory effect of Mani. FEBS letters, 586(19), 3018-3023.||Series/Report no.:||FEBS letters||Abstract:||Mani (myelin-associated neurite-outgrowth inhibitor) protein is implicated in both axonal guidance and axonal regeneration after central nervous system (CNS) injury. Here, we applied a neurite outgrowth assay, coupled with a siRNA-driven investigation and immunocytochemistry, to unveil Mani’s axonal outgrowth inhibitory effect in embryonic rat cortical primary neurons in vitro. We further demonstrate Mani’s neuronal localization in comparison with a principal subunit, Cdc27, of the anaphase promoting complex (APC). Considering the protein structure of Mani obtained via a series of bio-computational studies, we propose a Cdc27-Mani-APC-related signalling pathway may be involved in CNS axon regeneration.||URI:||https://hdl.handle.net/10356/99385
|DOI:||http://dx.doi.org/10.1016/j.febslet.2012.06.043||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SBS Journal Articles|
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