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Title: Characterizing the neurite outgrowth inhibitory effect of Mani
Authors: Mishra, Manisha
Lee, Sachiko
Yamashita, Toshihide
Heese, Klaus
Lin, Michelle K.
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2012
Source: Mishra, M., Lee, S., Lin, M. K., Yamashita, T., & Heese, K. (2012). Characterizing the neurite outgrowth inhibitory effect of Mani. FEBS letters, 586(19), 3018-3023.
Series/Report no.: FEBS letters
Abstract: Mani (myelin-associated neurite-outgrowth inhibitor) protein is implicated in both axonal guidance and axonal regeneration after central nervous system (CNS) injury. Here, we applied a neurite outgrowth assay, coupled with a siRNA-driven investigation and immunocytochemistry, to unveil Mani’s axonal outgrowth inhibitory effect in embryonic rat cortical primary neurons in vitro. We further demonstrate Mani’s neuronal localization in comparison with a principal subunit, Cdc27, of the anaphase promoting complex (APC). Considering the protein structure of Mani obtained via a series of bio-computational studies, we propose a Cdc27-Mani-APC-related signalling pathway may be involved in CNS axon regeneration.
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