Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs
Lee, Wei Li
Loo, Say Chye Joachim
Date of Issue2013
School of Materials Science and Engineering
Floating polymeric microcapsules that simultaneously entrap multiple drugs were prepared using a solid/water/oil/water emulsion solvent evaporation method, based on harnessing interfacial phenomena and manipulation of the solvent removal process. The fabricated microcapsules exhibited excellent buoyancy in simulated gastric fluid and provided controlled and sustained release of multiple drugs for up to 24 h, thus revealing their potential as a rate-controlled oral drug delivery system.
Journal of materials chemistry B
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