Weak arene C - H⋅⋅⋅O hydrogen bonding in palladium-catalyzed arylation and vinylation of lactones
Lim, Li Hui
Quang, Gia Chuong Phan
Zhou, Jianrong Steve
Date of Issue2013
School of Physical and Mathematical Sciences
Weak force in action: In the title reaction, the palladium catalyst (see figure, left) uses weak CH⋅⋅⋅O hydrogen bonding to control the absolute configuration of the new stereocenter. A similar palladium catalyst (right) used conventional NH⋅⋅⋅O hydrogen bonding to guide stereoselection.
Angewandte chemie international edition