Recent Submissions

  • Comparative epidemiology of vancomycin-resistant enterococci colonization in an acute-care hospital and its affiliated intermediate- and long-term care facilities in Singapore 

    Tan, Damon; Htun, Htet Lin; Koh, Jocelyn; Kanagasabai, Kala; Lim, Jia-Wei; Hon, Pei-Yun; Ang, Brenda; Chow, Angela (2018)
    Vancomycin-resistant enterococci (VRE) are an important cause of nosocomial infections in acute-care hospitals (ACHs), intermediate-care facilities (ITCFs), and long-term care facilities (LTCFs). This study contemporaneously ...
  • Carriage of Neisseria meningitidis in the Hajj and Umrah mass gatherings 

    Yezli, Saber; Wilder-Smith, Annelies; Abdulaziz A. Bin Saeed (2016)
    Meningococcal disease is a serious public health threat, especially during mass gatherings such as Hajj and Umrah which provide optimal conditions for disease transmission. The disease is caused by Neisseria meningitidis ...
  • Yellow fever cases in Asia: primed for an epidemic 

    Wasserman, Sean; Tambyah, Paul Anantharajah; Lim, Poh Lian (2016)
    There is currently an emerging outbreak of yellow fever in Angola. Cases in infected travellers have been reported in a number of other African countries, as well as in China, representing the first ever documented cases ...
  • Serious gaming and gamification interventions for health professional education 

    Gentry, Sarah; L'Estrade Ehrstrom, Beatrice; Gauthier, Andrea; Alvarez, Julian; Wortley, David; van Rijswijk, Jurriaan; Car, Josip; Lilienthal, Anneliese; Tudor Car, Lorainne; Nikolaou, Charoula K.; Zary, Nabil (2016)
    This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To evaluate the effectiveness of Serious Gaming and Gamification interventions for delivering pre‐ and post‐registration health ...
  • Offline and computer‐based elearning interventions for medical students' education 

    Hervatis, Vasilis; Kyaw, Bhone Myint; Semwal, Monika; Dunleavy, Gerard; Tudor Car, Lorainne; Zary, Nabil; Car, Josip (2016)
    This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The primary objective of this review is to assess the effects of offline, computer‐based eLearning compared with ‘traditional’ learning ...
  • Virtual reality environments for health professional education 

    Saxena, Nakul; Kyaw, Bhone Myint; Vseteckova, Jitka; Dev, Parvati; Paul, Pradeep; Lim, Kenneth Teck Kiat; Kononowicz, Andrzej; Masiello, Italo; Tudor Car, Lorainne; Nikolaou, Charoula K.; Zary, Nabil; Car, Josip (2016)
    This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of virtual reality environment (VRE)‐based educational interventions for health professionals on knowledge, ...
  • The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis 

    Leow, Shi Chi; Poschmann, Jeremie; Too, Peh Gek; Yin, Juan; Joseph, Roy; McFarlane, Craig; Dogra, Shaillay; Shabbir, Asim; Ingham, Philip William; Prabhakar, Shyam; Leow, Melvin K. S.; Lee, Yung Seng; Ng, Kai Lyn; Chong, Yap Seng; Gluckman, Peter D.; Stünkel, Walter (2016)
    An association between impaired fetal growth and the postnatal development of obesity has been established. Here, by comparing adipocytes differentiated from mesenchymal stem cells (MSCs) taken from the umbilical cord and ...
  • Intracerebral haemorrhage in down syndrome: protected or predisposed? 

    Buss, Lewis; Fisher, Elizabeth; Hardy, John; Nizetic, Dean; Groet, Jurgen; Pulford, Laura; Strydom, André (2016)
    Down syndrome (DS), which arises from trisomy of chromosome 21, is associated with deposition of large amounts of amyloid within the central nervous system. Amyloid accumulates in two compartments: as plaques within the ...
  • Virtual patient simulations for health professional education 

    Kononowicz, Andrzej A.; Woodham, Luke; Georg, Carina; Edelbring, Samuel; Stathakarou, Natalia; Davies, David; Masiello, Italo; Saxena, Nakul; Tudor Car, Lorainne; Car, Josip; Zary, Nabil (2016)
    This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The objective of this review is to evaluate the effectiveness of virtual patient simulation as an educational intervention versus ...
  • Heat sepsis precedes heat toxicity in the pathophysiology of heat stroke—a new paradigm on an ancient disease 

    Lim, Chin Leong (2018)
    Heat stroke (HS) is an ancient illness dating back more than 2000 years and continues to be a health threat and to cause fatality during physical exertion, especially in military personnel, fire-fighters, athletes, and ...
  • Melanogenesis Inhibitors 

    Kumari, Sulekha; Thng, Steven Tien Guan; Verma, Navin Kumar; Gautam, Hemant K. (2018)
    Abnormally high production of melanin or melanogenesis in skin melanocytes results in hyperpigmentation disorders, such as melasma, senile lentigines or freckles. These hyperpigmentary skin disorders can significantly ...
  • Offline and computer‐based eLearning interventions for medical doctors' education 

    Semwal, Monika; Wahabi, Hayfaa A.; Posadzki, Pawel; Divakar, Ushashree; Lim, Kenneth Teck Kiat; Audouard-Marzin, Youna; Zary, Nabil; Tudor Car, Lorainne (2016)
    This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The primary objective of this systematic review is to evaluate the effectiveness of offline computer‐based eLearning educational ...
  • Structural complexity of filaments formed from the actin and tubulin folds 

    Jiang, Shimin; Ghoshdastider, Umesh; Narita, Akihiro; Popp, David; Robinson, Robert Charles (2016)
    From yeast to man, an evolutionary distance of 1.3 billion years, the F-actin filament structure has been conserved largely in line with the 94% sequence identity. The situation is entirely different in bacteria. In ...
  • Asymmetric dimethylarginine in adult falciparum malaria: relationships with disease severity, antimalarial treatment, hemolysis, and inflammation 

    Barber, Bridget E.; William, Timothy; Grigg, Matthew J.; Parameswaran, Uma; Piera, Kim A.; Yeo, Tsin Wen; Anstey, Nicholas M. (2016)
    Background: Endothelial nitric oxide (NO) bioavailability is impaired in severe falciparum malaria (SM). Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase (NOS), contributes to endothelial dysfunction ...
  • Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise 

    Chooi, Yu Chung; Ding, Cherlyn; Chan, Zhiling; Lo, Jezebel; Choo, John; Ding, Benjamin T. K.; Leow, Melvin Khee-Shing; Magkos, Faidon (2018)
    Weight loss, induced by chronic energy deficit, improves the blood lipid profile. However, the effects of an acute negative energy balance and the comparative efficacy of diet and exercise are not well-established. We ...
  • Early developmental perturbations in a human stem cell model of MODY5/HNF1B pancreatic hypoplasia 

    Teo, Adrian Kee Keong; Lau, Hwee Hui; Valdez, Ivan Achel; Dirice, Ercument; Tjora, Erling; Raeder, Helge; Kulkarni, Rohit N. (2016)
    Patients with an HNF1BS148L/+ mutation (MODY5) typically exhibit pancreatic hypoplasia. However, the molecular mechanisms are unknown due to inaccessibility of patient material and because mouse models do not fully ...
  • Hyperlipidemia, statin use and dengue severity 

    Chia, Po Ying; Htun, Htet Lin; Ling, Wei Ping; Leo, Yee Sin; Yeo, Tsin Wen; Lye, David Chien Boon (2018)
    Multiple in vitro and mice model studies suggest statins may attenuate dengue severity. However, little is known about statin use and dengue severity in adult dengue patients with hyperlipidemia. We conducted a retrospective ...
  • Localization of α 2u-globulin in the acinar cells of preputial gland, and confirmation of its binding with farnesol, a putative pheromone, in field rat (Millardia meltada) 

    Rajamanickam, Ramachandran; Shanmugam, Achiraman; Thangavel, Rajagopal; Devaraj, Sankarganesh; Soundararajan, Kamalakkannan; Ponnirul, Ponmanickam; Ramalingam, Rajkumar; Ganesan, Ramya Vaideki; Parasuraman, Padmanabhan; Govindaraju, Archunan (2018)
    Pheromones, low molecular weight chemical entities that bind to pheromone carrier proteins, are chemical signals that play an important role in the communication system in animals. This has been rather fairly well-studied ...
  • Evaluation of flicker induced hyperemia in the retina and optic nerve head measured by Laser Speckle Flowgraphy 

    Fondi, Klemens; Bata, Ahmed M.; Luft, Nikolaus; Witkowska, Katarzyna J.; Werkmeister, René M.; Schmidl, Doreen; Bolz, Matthias; Schmetterer, Leopold; Garhöfer, Gerhard (2018)
    Purpose: The coupling between neural activity and blood flow is a physiological key principle of ocular blood flow regulation. The current study was performed to investigate whether Laser speckle flowgraphy (LSFG), a ...
  • Mothers after gestational diabetes in Australia (MAGDA): a randomised controlled trial of a postnatal diabetes prevention program 

    O’Reilly, Sharleen L.; Dunbar, James A.; Versace, Vincent; Janus, Edward; Best, James D.; Carter, Rob; Oats, Jeremy J. N.; Skinner, Timothy; Ackland, Michael; Phillips, Paddy A.; Ebeling, Peter R.; Reynolds, John; Shih, Sophy T. F.; Hagger, Virginia; Coates, Michael; Wildey, Carol (2016)
    Background: Gestational diabetes mellitus (GDM) is an increasingly prevalent risk factor for type 2 diabetes. We evaluated the effectiveness of a group-based lifestyle modification program in mothers with prior GDM within ...

View more