Recent Submissions

  • Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner 

    Thion, Morgane Sonia; Low, Donovan; Silvin, Aymeric; Chen, Jinmiao; Grisel, Pauline; Schulte-Schrepping, Jonas; Blecher, Ronnie; Ulas, Thomas; Squarzoni, Paola; Hoeffel, Guillaume; Coulpier, Fanny; Siopi, Eleni; David, Friederike Sophie; Scholz, Claus; Foo, Shihui; Lum, Josephine; Amoyo, Arlaine Anne; Larbi, Anis; Poidinger, Michael; Buttgereit, Anne; Lledo, Pierre-Marie; Greter, Melanie; Chan, Jerry Kok Yen; Amit, Ido; Beyer, Marc; Schultze, Joachim Ludwig; Schlitzer, Andreas; Pettersson, Sven; Ginhoux, Florent; Garel, Sonia (2017)
    Microglia are embryonically seeded macrophages that contribute to brain development, homeostasis, and pathologies. It is thus essential to decipher how microglial properties are temporally regulated by intrinsic and extrinsic ...
  • Our Gut Microbiome: The Evolving Inner Self 

    Kundu, Parag; Blacher, Eran; Elinav, Eran; Pettersson, Sven (2017)
    The “holobiont” concept, defined as the collective contribution of the eukaryotic and prokaryotic counterparts to the multicellular organism, introduces a complex definition of individuality enabling a new comprehensive ...
  • Theranostic Probes for Targeting Tumor Microenvironment: An Overview 

    Sikkandhar, Musafar Gani; Nedumaran, Anu Maashaa; Ravichandar, Roopa; Singh, Satnam; Santhakumar, Induja; Goh, Zheng Cong; Mishra, Sachin; Archunan, Govindaraju; Gulyás, Balázs; Padmanabhan, Parasuraman (2017)
    Long gone is the time when tumors were thought to be insular masses of cells, residing independently at specific sites in an organ. Now, researchers gradually realize that tumors interact with the extracellular matrix ...
  • MEG Insight into the Spectral Dynamics Underlying Steady Isometric Muscle Contraction 

    Bourguignon, Mathieu; Piitulainen, Harri; Smeds, Eero; Zhou, Guangyu; Jousmäki, Veikko; Hari, Riitta (2017)
    To gain fundamental knowledge on how the brain controls motor actions, we studied in detail the interplay between MEG signals from the primary sensorimotor (SM1) cortex and the contraction force of 17 healthy adult humans ...
  • Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells 

    Gomzikova, Marina O.; Zhuravleva, Margarita N.; Miftakhova, Regina R.; Arkhipova, Svetlana S.; Evtugin, Vladimir G.; Khaiboullina, Svetlana F.; Kiyasov, Andrey P.; Persson, Jenny L.; Mongan, Nigel P.; Pestell, Richard George; Rizvanov, Albert A. (2017)
    Naturally occurring extracellular vesicles (EVs) play essential roles in intracellular communication and delivery of bioactive molecules. Therefore it has been suggested that EVs could be used for delivery of therapeutics. ...
  • Susceptibility Testing for the Polymyxins: Two Steps Back, Three Steps Forward? 

    Vasoo, Shawn (2017)
    Optimizing and standardizing susceptibility testing for the polymyxins have become pressing issues, given the rise in multidrug-resistant Gram-negative bacilli. Recently, both the CLSI and EUCAST have recommended broth ...
  • Progress and Challenges towards Point-of-Care Diagnostic Development for Dengue 

    Pang, Junxiong; Chia, Po Ying; Lye, David Chien Boon; Leo, Yee Sin (2017)
    Dengue detection strategies involve viral RNA, antigen, and/or antibody detection. Each strategy has its advantages and disadvantages. Optimal, user-friendly, rapid diagnostic tests based on immunochromatographic assays ...
  • Impact of a Carbapenem Antimicrobial Stewardship Program on Patient Outcomes 

    Seah, Valerie Xue Fen; Ong, Rina Yue Ling; Lim, Ashley Shi Yuan; Chong, Chia Yin; Tan, Natalie Woon Hui; Thoon, Koh Cheng (2017)
    Antimicrobial stewardship programs (ASPs) aim to improve appropriate antimicrobial use. However, concerns of the negative consequences from accepting ASP interventions exist, particularly when deescalation or discontinuation ...
  • Bedaquiline Inhibits the ATP Synthase in Mycobacterium abscessus and Is Effective in Infected Zebrafish 

    Dupont, Christian; Viljoen, Albertus; Thomas, Sangeeta; Roquet-Banères, Françoise; Herrmann, Jean-Louis; Pethe, Kevin; Kremer, Laurent (2017)
    Pulmonary infections caused by Mycobacterium abscessus are emerging as a global threat, especially in cystic fibrosis patients. Further intensifying the concern of M. abscessus infection is the recent evidence of human-to-human ...
  • Cavin-2 regulates the activity and stability of endothelial nitric-oxide synthase (eNOS) in angiogenesis 

    Boopathy, Gandhi T. K.; Kulkarni, Madhura; Ho, Sze Yuan; Boey, Adrian; Chua, Edmond Wei Min; Barathi, Veluchamy A.; Carney, Tom J.; Wang, Xiaomeng; Hong, Wanjin (2017)
    Angiogenesis is a highly regulated process for formation of new blood vessels from pre-existing ones. Angiogenesis is dysregulated in various pathologies, including age-related macular degeneration, arthritis, and cancer. ...
  • Structure of the competence pilus major pilin ComGC in Streptococcus pneumoniae 

    Muschiol, Sandra; Erlendsson, Simon; Aschtgen, Marie-Stephanie; Oliveira, Vitor; Schmieder, Peter; De Lichtenberg, Casper; Teilum, Kaare; Boesen, Thomas; Akbey, Umit; Henriques-Normark, Birgitta (2017)
    Type IV pili are important virulence factors on the surface of many pathogenic bacteria and have been implicated in a wide range of diverse functions, including attachment, twitching motility, biofilm formation, and ...
  • Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation 

    Chu, Trang T. T.; Sinha, Ameya; Malleret, Benoit; Suwanarusk, Rossarin; Park, Jung Eun; Naidu, Renugah; Das, Rupambika; Dutta, Bamaprasad; Ong, Seow Theng; Verma, Navin Kumar; Chan, Jerry K.; Nosten, François; Rénia, Laurent; Sze, Siu Kwan; Russell, Bruce; Chandramohanadas, Rajesh (2017)
    Erythropoiesis is marked by progressive changes in morphological, biochemical and mechanical properties of erythroid precursors to generate red blood cells (RBC). The earliest enucleated forms derived in this process, known ...
  • How cognitive engagement fluctuates during a team-based learning session and how it predicts academic achievement 

    Rotgans, Jerome Ingmar; Schmidt, Hendricus Gerard; Rajalingam, Preman; Wong, Joey Ying Hao; Canning, Claire Ann; Ferenczi, Michael Alan; Low-Beer, Naomi (2017)
    The objective of the paper is to report findings of two studies that attempted to find answers to the following questions: (1) What are the levels of cognitive engagement in TBL? (2) Are there differences between students ...
  • A Novel Microdevice for Rapid Neutrophil Purification and Phenotyping in Type 2 Diabetes Mellitus 

    Tay, Hui Min; Dalan, Rinkoo; Li, Holden King Ho; Boehm, Bernhard Otto; Hou, Han Wei (2017)
    Neutrophil dysfunction is strongly linked to type 2 diabetes mellitus (T2DM) pathophysiology, but the prognostic potential of neutrophil biomarkers remains largely unexplored due to arduous leukocyte isolation methods. ...
  • Macrophage–Bacteria Interactions—A Lipid-Centric Relationship 

    Teng, Ooiean; Ang, Candice Ke En; Guan, Xue Li (2017)
    Macrophages are professional phagocytes at the front line of immune defenses against foreign bodies and microbial pathogens. Various bacteria, which are responsible for deadly diseases including tuberculosis and salmonellosis, ...
  • Assessing How Students Learn in Team-Based Learning: Validation of the Knowledge Re-Consolidation Inventory 

    Ahn, Hyun Seon; Rotgans, Jerome Ingmar; Rajalingam, Preman; Lee, Rebekah Jian Jia; Koh, Juliana Ying Yun; Low-Beer, Naomi (2017)
    Purpose: The purpose of the present study was to establish the construct validity of a new instrument to measure psychological learning processes associated with Team-based learning (TBL), the Knowledge Re-Consolidation ...
  • Ca 2+ releases E‐Syt1 autoinhibition to couple ER‐plasma membrane tethering with lipid transport 

    Bian, Xin; Saheki, Yasunori; De Camilli, Pietro (2017)
    The extended synaptotagmins (E-Syts) are endoplasmic reticulum (ER) proteins that bind the plasma membrane (PM) via C2 domains and transport lipids between them via SMP domains. E-Syt1 tethers and transports lipids in a ...
  • Measuring the bias against low-income country research: an Implicit Association Test 

    Harris, Matthew; Macinko, James; Jimenez, Geronimo; Mullachery, Pricila (2017)
    Background: With an increasing array of innovations and research emerging from low-income countries there is a growing recognition that even high-income countries could learn from these contexts. It is well known that the ...
  • Sexual behaviors among methadone maintenance patients in a mountainous area in northern Vietnam 

    Boggiano, Victoria L.; Nguyen, Huong Lan Thi; Nguyen, Long Hoang; Tran, Tho Dinh; Van Nguyen, Hung; Le, Huong Thi; Le, Hai Quan; Hoang, Canh Dinh; Nguyen, Cuong Tat; Tran, Bach Xuan; Latkin, Carl A.; Zary, Nabil; Vu, Thuc Minh Thi (2017)
    Background: Methadone maintenance treatment (MMT) improves patients’ ability to access HIV-related services and reduces needle sharing and other risky HIV-related behaviors. However, patients may continue to engage in risky ...
  • Optical inhibition of larval zebrafish behaviour with anion channelrhodopsins 

    Mohamed, Gadisti Aisha; Cheng, Ruey-Kuang; Ho, Joses; Krishnan, Seetha; Mohammad, Farhan; Claridge-Chang, Adam; Jesuthasan, Suresh (2017)
    Optical silencing of activity provides a way to test the necessity of neurons in behaviour. Two light-gated anion channels, GtACR1 and GtACR2, have recently been shown to potently inhibit activity in cultured mammalian ...

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