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Contribution of lower physical activity levels to higher risk of insulin resistance and associated metabolic disturbances in South Asians compared to Europeans
(2019)Background : Insulin resistance and related metabolic disturbances are major risk factors for the higher T2D risk and associated morbidity and mortality amongst South Asians. The contribution of physical activity to the ... -
Food allergy knowledge, attitudes and their determinants among restaurant staff : a cross-sectional study
(2019)Background : There is wide international variation regarding food allergy knowledge among restaurant staff. Further, attitudes towards food allergy remain under-researched. Insights into the independent determinants of ... -
Individual, clinical and system factors associated with the place of death : a linked national database study
(2019)Background : Many middle- and high-income countries face the challenge of meeting preferences for home deaths. A better understanding of associated factors could support the design and implementation of policies and practices ... -
Digital health at fifteen : more human (more needed)
(2019)There is growing appreciation that the success of digital health – whether digital tools, digital interventions or technology-based change strategies – is linked to the extent to which human factors are considered throughout ... -
Evaluation of a targeted, theory-informed implementation intervention designed to increase uptake of emergency management recommendations regarding adult patients with mild traumatic brain injury : results of the NET cluster randomised trial
(2019)Background : Evidence-based guidelines for management of mild traumatic brain injury (mTBI) in the emergency department (ED) are now widely available; however, clinical practice remains inconsistent with these guidelines. ... -
Pre- and apnoeic high flow oxygenation for RApid sequence intubation in the emergency department (pre-AeRATE) : study protocol for a multicentre, randomised controlled trial
(2019)Background : Maintaining adequate oxygenation during rapid sequence intubation (RSI) is imperative to prevent peri-intubation adverse events that can lead to increased duration of hospital and intensive care unit stay, or ... -
Update on the general practice optimising structured monitoring to improve clinical outcomes in type 2 diabetes (GP-OSMOTIC) trial : statistical analysis plan for a multi-centre randomised controlled trial
(2019)Background : General Practice Optimising Structured Monitoring to Improve Clinical Outcomes in Type 2 Diabetes (GP-OSMOTIC) is a multicentre, individually randomised controlled trial aiming to compare the use of intermittent ... -
Non-verbal speech cues as objective measures for negative symptoms in patients with schizophrenia
(2019)Negative symptoms in schizophrenia are associated with significant burden and possess little to no robust treatments in clinical practice today. One key obstacle impeding the development of better treatment methods is the ... -
Trends in subjective quality of life among patients with first episode psychosis — a 1 year longitudinal study
(2019)Quality of life (QoL) is often used as an outcome assessment in programs treating patients with first-episode psychosis (FEP). The aim of this study was to examine the longitudinal trend of subjective QoL among patients ... -
Motoric cognitive risk syndrome : could it be defined through increased five-times-sit-to-stand test time, rather than slow walking speed?
(2019)Background: Slow walking speed, time to perform the five-times-sit-to-stand (FTSS) test and motoric cognitive risk syndrome (MCR; defined as slow gait speed combined with subjective cognitive complaint) have been separately ... -
Incorporating participatory action research in attention bias modification interventions for addictive disorders : perspectives
(2019)Participatory action research was introduced in the 1960s and early 1970s, but it has only been more widely adopted in the recent years. Such methodologies have since been applied to several web & mobile-based interventions ... -
Depletion of gram-positive bacteria impacts hepatic biological functions during the light phase
(2019)Living organisms display internal biological rhythms, which are an evolutionarily conserved adaptation to the environment that drives their rhythmic behavioral and physiological activities. The gut microbiota has been ... -
The combined diabetes and renal control trial (C-DIRECT) - a feasibility randomised controlled trial to evaluate outcomes in multi-morbid patients with diabetes and on dialysis using a mixed methods approach
(2019)Background: This cluster randomised controlled trial set out to investigate the feasibility and acceptability of the “Combined Diabetes and Renal Control Trial” (C-DIRECT) intervention, a nurse-led intervention based on ... -
Iron status and risk factors of iron deficiency among pregnant women in Singapore : a cross-sectional study
(2019)Background: Iron deficiency is the most prevalent nutrient deficiency and the most common cause of anaemia worldwide. Because of the increased iron requirements during pregnancy, iron deficiency can lead to maternal anaemia ... -
Can support workers from AgeUK deliver an intervention to support older people with anxiety and depression? a qualitative evaluation
(2019)Background: Anxiety and depression often co-exist. These disorders are under-diagnosed and under-treated, specifically among older people, and lead to increased use of health and social care services and raised mortality. ... -
Postmortem evidence of disseminated Zika virus infection in an adult patient
(2019)Fatal complications associated with the Zika virus (ZIKV) have rarely been reported in adults, and detailed postmortem reports are limited (Musso and Gubler, 2016). ZIKV infection is typically a mild uncomplicated febrile ... -
Digital education for the management of chronic wounds in health care professionals : protocol for a systematic review by the digital health education collaboration
(2019)Background: Digital education is “the act of teaching and learning by means of digital technologies.” Digital education comprises a wide range of interventions that can be broadly divided into offline digital education, ... -
ROS release by PPARβ/δ-null fibroblasts reduces tumor load through epithelial antioxidant response
(2018)Tumor stroma has an active role in the initiation, growth, and propagation of many tumor types by secreting growth factors and modulating redox status of the microenvironment. Although PPARβ/δ in fibroblasts was shown to ... -
An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1
(2019)Tissue-type plasminogen activator (tPA) is a major mediator of fibrinolysis and, thereby, prevents excessive coagulation without compromising hemostasis. Studies on tPA regulation have focused on its acute local release ... -
Rapid discovery of the potential toxic compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-based metabolomics and correlation analysis
(2019)The dry roots of Polygonum multiflorum (PM), involving both the raw and processed materials, are widely used as the traditional Chinese medicine for treating various diseases in China. Hepatotoxicity has been occasionally ...
