• A group-based lifestyle intervention for diabetes prevention in low- and middle-income country : implementation evaluation of the Kerala Diabetes Prevention Program 

  Aziz, Zahra; Mathews, Elezebeth; Absetz, Pilvikki; Sathish, Thirunavukkarasu; Oldroyd, John; Balachandran, Sajitha; Shetty, Suman S.; Thankappan, K. R.; Oldenburg, Brian (2018)

  Background: While several efficacy trials have demonstrated diabetes risk reduction through targeting key lifestyle behaviours, there is a significant evidence gap in relation to the successful implementation of such ...

• Associations between post-operative rehabilitation of hip fracture and outcomes : national database analysis (90 characters) 

  Su, Bowen; Newson, Roger; Soljak, Harry; Soljak, Michael (2018)

  Background: Rehabilitation programmes are used to improve hip fracture outcomes. There is little published trial clinical trial or population-based data on the effects of the type or provider of rehabilitation treatments ...

• Kinetics of functional beta cell mass decay in a diphtheria toxin receptor mouse model of diabetes 

  van Krieken, Pim P.; Dicker, Andrea; Eriksson, Maria; Herrera, Pedro L.; Ahlgren, Ulf; Berggren, Per-Olof; Ilegems, Erwin (2017)

  Functional beta cell mass is an essential biomarker for the diagnosis and staging of diabetes. It has however proven technically challenging to study this parameter during diabetes progression. Here we have detailed the ...

• Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus 

  Tam, Zhi Yang; Ng, Sean Pin; Tan, Ling Qiao; Lin, Chih-Hsien; Rothenbacher, Dietrich; Klenk, Jochen; Boehm, Bernhard Otto; Goh, Kelvin Kau Kiat; Suwanchaikasem, Pipob; Tipthara, Pornpimol; Yang, Song Yi; Becker, T.; Stingl, J.; Koenig, W.; Riepe, M.; Peter, R.; Geiger, H.; Ludolph, A.; Arnim, C. v.; Nagel, G.; Weinmayr, G.; Rapp, K.; Denkinger, M. D.; Dallmeier, D.; Steinacker, J. M.; Laszlo, R. (2017)

  Regulation of blood glucose requires precise coordination between different endocrine systems and multiple organs. Type 2 diabetes mellitus (T2D) arises from a dysregulated response to elevated glucose levels in the ...

• Ocular fundus pulsations within the posterior rat eye : chorioscleral motion and response to elevated intraocular pressure 

  Augustin, Marco; Fialová, Stanislava; Fischak, Corinna; Schmetterer, Leopold; Hitzenberger, Christoph K.; Baumann, Bernhard (2017)

  A multi-functional optical coherence tomography (OCT) approach is presented to determine ocular fundus pulsations as an axial displacement between the retina and the chorioscleral complex in the albino rat eye. By combining ...

• Identification of antibacterial components in human hair shafts 

  Subbaiah, Roopa S.; Kerk, Swat Kim; Lian, Yilong; Lunny, Declan; Sze, Siu Kwan; Ng, Kee Woei; Schmidtchen, Artur; Adav, Sunil Shankar (2018)

  Antimicrobial peptides (AMPs) are evolutionarily old components of innate immunity. AMPs identified in human skin include defensins, cathelicidin, dermcidin, psoriasin, and RNase7 (1, 2). Some AMPs, such as the human ...

• Leptospirosis among returned travelers : a GeoSentinel site survey and multicenter analysis—1997–2016 

  de Vries, Sophia G.; Visser, Benjamin J.; Stoney, Rhett J.; Wagenaar, Jiri F. P.; Bottieau, Emmanuel; Chen, Lin H.; Wilder-Smith, Annelies; Wilson, Mary; Rapp, Christophe; Leder, Karin; Caumes, Eric; Schwartz, Eli; Hynes, Noreen A.; Goorhuis, Abraham; Esposito, Douglas H.; Hamer, Davidson H.; Grobusch, Martin P. (2018)

  Leptospirosis is a potentially fatal emerging zoonosis with worldwide distribution and a broad range of clinical presentations and exposure risks. It typically affects vulnerable populations in (sub)tropical countries but ...

• Progress in exosome isolation techniques 

  Li, Pin; Kaslan, Melisa; Lee, Sze Han; Yao, Justin; Gao, Zhiqiang (2017)

  Exosomes are one type of membrane vesicles secreted into extracellular space by most types of cells. In addition to performing many biological functions particularly in cell-cell communication, cumulative evidence has ...

• Improving health aid for a better planet : the planning, monitoring and evaluation tool (PLANET) 

  Sridhar, Devi; Car, Josip; Chopra, Mickey; Campbell, Harry; Woods, Ngaire; Rudan, Igor (2017)

  BACKGROUND : International development assistance for health (DAH) quadrupled between 1990 and 2012, from US$ 5.6 billion to US$ 28.1 billion. This generates an increasing need for transparent and replicable tools that ...

• Comparison of text messaging data collection vs face-to-face interviews for public health surveys : a cluster randomized crossover study of care-seeking for childhood pneumonia and diarrhoea in rural China 

  van Velthoven, Michelle Helena; Wang, Wei; Wu, Qiong; Li, Ye; Scherpbier, Robert W; Du, Xiaozhen; Chen, Li; Zhang, Yanfeng; Car, Josip; Rudan, Igor (2018)

  Background: To compare text messaging and face-to-face interviews to conduct a survey on childhood diarrhoea and pneumonia. Methods: Caregivers of young children able to send text messages in Zhao County in rural China ...

• Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth 

  Pestell, Timothy G.; Jiao, Xuanmao; Kumar, Mukesh; Peck, Amy R.; Prisco, Marco; Deng, Shengqiong; Li, Zhiping; Ertel, Adam; Casimiro, Mathew C.; Ju, Xiaoming; Di Rocco, Agnese; Di Sante, Gabriele; Katiyar, Sanjay; Shupp, Alison; Lisanti, Michael P.; Jain, Pooja; Wu, Kongming; Rui, Hallgeir; Hooper, Douglas C.; Yu, Zuoren; Goldman, Aaron R.; Speicher, David W.; Laury-Kleintop, Lisa; Pestell, Richard G. (2017)

  The cyclin D1 gene encodes the regulatory subunit of a holoenzyme that drives cell autonomous cell cycle progression and proliferation. Herein we show cyclin D1 abundance is increased >30-fold in the stromal fibroblasts ...

• Enhancing the quality and utility of content analyses for addictive disorders 

  Zhang, Melvyn; Wing, Tracey; Fung, Daniel S. S.; Smith, Helen (2018)

  The advances in Mobile Health (M-health) technologies has led to an increase in the numbers of alcohol and drugs applications on the commercial stores. Content analyses and reviews of applications to date have demonstrated ...

• Functional regulation of ppars through post-translational modifications 

  Brunmeir, Reinhard; Xu, Feng (2018)

  Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily and they are essential regulators of cell differentiation, tissue development, and energy metabolism. Given their central roles ...

• Insights into the role of PPARβ/δ in NAFLD 

  Chen, Jiapeng; Montagner, Alexandra; Tan, Nguan Soon; Wahli, Walter (2018)

  Non-alcoholic fatty liver disease (NAFLD) is a major health issue in developed countries. Although usually associated with obesity, NAFLD is also diagnosed in individuals with low body mass index (BMI) values, especially ...

• A peer-support lifestyle intervention for preventing type 2 diabetes in India : a cluster-randomized controlled trial of the Kerala Diabetes Prevention Program 

  Thankappan, Kavumpurathu R.; Sathish, Thirunavukkarasu; Tapp, Robyn J.; Shaw, Jonathan E.; Lotfaliany, Mojtaba; Wolfe, Rory; Absetz, Pilvikki; Mathews, Elezebeth; Aziz, Zahra; Williams, Emily D.; Fisher, Edwin B.; Zimmet, Paul Z.; Mahal, Ajay; Balachandran, Sajitha; D'Esposito, Fabrizio; Sajeev, Priyanka; Thomas, Emma; Oldenburg, Brian (2018)

  Background: The major efficacy trials on diabetes prevention have used resource-intensive approaches to identify high-risk individuals and deliver lifestyle interventions. Such strategies are not feasible for wider ...

• Peroxisome proliferator activated receptor gamma controls mature brown adipocyte inducibility through glycerol kinase 

  Lasar, David; Rosenwald, Matthias; Kiehlmann, Elke; Balaz, Miroslav; Tall, Bettina; Opitz, Lennart; Lidell, Martin E.; Zamboni, Nicola; Krznar, Petra; Sun, Wenfei; Varga, Lukas; Stefanicka, Patrik; Ukropec, Jozef; Nuutila, Pirjo; Virtanen, Kirsi; Amri, Ez-Zoubir; Enerbäck, Sven; Wahli, Walter; Wolfrum, Christian (2018)

  Peroxisome proliferator-activated receptors (PPARs) have been suggested as the master regulators of adipose tissue formation. However, their role in regulating brown fat functionality has not been resolved. To address this ...

• Upregulation of epidermal gap junctional proteins in patients with venous disease 

  Kanapathy, Muholan; Simpson, R.; Madden, Leigh; Thrasivoulou, C.; Mosahebi, A.; Becker, David Lawrence; Richards, T. (2017)

  Background Leg ulceration is a feared complication of venous insufficiency. It is not known whether varicose veins predispose skin to poor wound healing. The expression pattern of gap junctional protein connexin, a known ...

• The relationship of dietary fish intake to diabetic retinopathy and retinal vascular caliber in patients with type 2 diabetes 

  Chua, Jacqueline; Chia, Ai-Ru; Chee, Miao Li; Man, Ryan Eyn Kidd; Tan, Gavin Siew Wei; Lamoureux, Ecosse L.; Wong, Tien Yin; Chong, Mary Foong-Fong; Schmetterer, Leopold (2018)

  In this cross-sectional study, we evaluated the association of dietary fish intake with varying severity of diabetic retinopathy (DR) and retinal vascular caliber in Asians with type 2 diabetes mellitus. 357 Asians (median ...

• Studies on the proteome of human hair - identification of histones and deamidated keratins 

  Adav, Sunil Shankar; Subbaiaih, Roopa Shree; Kerk, Swat Kim; Lee, Amelia Yilin; Lai, Hui Ying; Ng, Kee Woei; Sze, Siu Kwan; Schmidtchen, Artur (2018)

  Human hair is laminar-fibrous tissue and an evolutionarily old keratinization product of follicle trichocytes. Studies on the hair proteome can give new insights into hair function and lead to the development of novel ...

• Correlation of clinical illness with viremia in Zika virus disease during an outbreak in Singapore 

  Ng, Deborah H. L.; Ho, Hanley J.; Chow, Angela; Wong, Joshua; Kyaw, Win Mar; Tan, Adriana; Chia, Po Ying; Choy, Chiaw Yee; Tan, Glorijoy; Yeo, Tsin Wen; Leo, Yee Sin (2018)

  Background: The first autochthonous Zika virus (ZIKV) outbreak in Singapore was detected in August 2016. We report an analysis of the correlation of clinical illness with viremia and laboratory parameters in this Asian ...

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