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Dual PPARα/γ agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH models
(2017)Background & Aims: Non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH) are common clinico‐pathological conditions that affect millions of patients worldwide. In this study, the efficacy of ... -
Chymase level is a predictive biomarker of dengue hemorrhagic fever in pediatric and adult patients
(2017)Background: Most patients with dengue experience mild disease, dengue fever (DF), while few develop the life-threatening diseases dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). No laboratory tests predict ... -
Screening of ferrocenyl–phosphines identifies a gold-coordinated derivative as a novel anticancer agent for hematological malignancies
(2018)The development of new organometallic compounds as anticancer agents is currently an active area of research. Here, we report the design, synthesis and characterization of a panel of 10 new ferrocenyl–phosphine derivatives ... -
Posterior rat eye during acute intraocular pressure elevation studied using polarization sensitive optical coherence tomography
(2017)Polarization sensitive optical coherence tomography (PS-OCT) operating at 840 nm with axial resolution of 3.8 µm in tissue was used for investigating the posterior rat eye during an acute intraocular pressure (IOP) increase ... -
Evaluating burden and quality of life among caregivers of patients receiving peritoneal dialysis
(2019)Peritoneal dialysis (PD) is advocated as treatment of choice for most end-stage renal disease (ESRD) patients, including elderly and frail patients. It typically requires caregiver involvement to support care at home. The ... -
Antibody treatment against angiopoietin-like 4 reduces pulmonary edema and injury in secondary pneumococcal pneumonia
(2019)Secondary bacterial lung infection by Streptococcus pneumoniae (S.pneumoniae) poses a serious health concern, especially in developing countries. We posit that the emergence of multiantibiotic-resistant strains will ... -
Patients' perceptions and factors affecting dialysis modality decisions
(2018)Background: Home-based dialysis, including peritoneal dialysis (PD) and home hemodialysis (HHD), has been shown to be associated with lower costs and higher health-related quality of life than in-center HD. However, factors ... -
Depression among patients with hiv/aids : research development and effective interventions (GAPRESEARCH)
(2019)Depression in people living with HIV (PLWH) has become an urgent issue and has attracted the attention of both physicians and epidemiologists. Currently, 39% of HIV patients are reported to suffer from depression. This ... -
A randomised controlled trial of a telephone administered brief HIV risk reduction intervention amongst men who have sex with men prescribed post-exposure prophylaxis for HIV after sexual exposure in the UK : project PEPSE
(2019)Background: In western countries, men who have sex with men (MSM) are most affected by HIV and increasingly likely to engage in risky sexual behaviour. MSM who experience a potential sexual exposure to HIV (PEPSE) and ... -
A 15-year review of dengue hospitalizations in Singapore : reducing admissions without adverse consequences, 2003 to 2017
(2019)Objectives: Since the 1990s, Singapore has experienced periodic dengue epidemics of increasing frequency and magnitude. In the aftermath of the 2004–2005 dengue epidemic, hospitals refined their admission criteria for ... -
Exosomes as emerging pro-tumorigenic mediators of the senescence-associated secretory phenotype
(2019)Communication between cells is quintessential for biological function and cellular homeostasis. Membrane-bound extracellular vesicles known as exosomes play pivotal roles in mediating intercellular communication in tumor ... -
Understanding the relation between Zika virus infection during pregnancy and adverse fetal, infant and child outcomes : a protocol for a systematic review and individual participant data meta-analysis of longitudinal studies of pregnant women and their infants and children
(2019)Introduction: Zika virus (ZIKV) infection during pregnancy is a known cause of microcephaly and other congenital and developmental anomalies. In the absence of a ZIKV vaccine or prophylactics, principal investigators (PIs) ... -
Carotid mycotic aneurysm associated with persistent primitive hypoglossal artery. Case report and literature review
(2019)Carotid mycotic aneurysm is extremely rare and even more unusual when it is associated with a persistent primitive hypoglossal artery. This artery is the second most common of the embryonic carotid-vertebrobasilar anastomoses. ... -
Persistent primitive trigeminal artery associated with a cavernous carotid aneurysm. Case report and literature review.
(2018)The persistent primitive trigeminal artery is the most common persistent carotid-vertebrobasilar anastomosis. Patients are usually asymptomatic and the persistent primitive trigeminal artery is commonly found incidentally ... -
Deciphering molecular mechanism of silver by integrated omic approaches enables enhancing its antimicrobial efficacy in E. coli
(2019)Despite the broad-spectrum antimicrobial activities of silver, its internal usage is restricted, owing to the toxicity. Strategies to enhance its efficacy are highly desirable but rely heavily on the understanding of its ... -
Finding the intersection of neuroplasticity, stroke recovery, and learning : scope and contributions to stroke rehabilitation
(2019)Aim. Neural plastic changes are experience and learning dependent, yet exploiting this knowledge to enhance clinical outcomes after stroke is in its infancy. Our aim was to search the available evidence for the core concepts ... -
Replacing meat with alternative plant-based products (RE-MAPs) : protocol for a randomised controlled trial of a behavioural intervention to reduce meat consumption
(2019)Introduction : Reducing meat consumption could contribute towards preventing some chronic conditions and protecting the natural environment. This study will examine the effectiveness of a behavioural intervention to reduce ... -
Reactive oxygen species : a volatile driver of field cancerization and metastasis
(2019)Field cancerization and metastasis are the leading causes for cancer recurrence and mortality in cancer patients. The formation of primary, secondary tumors or metastasis is greatly influenced by multifaceted tumor-stroma ... -
A novel type of neuron within the dorsal striatum
(2019)The striatum is predominantly composed of medium spiny projection neurons, with the remaining neurons consisting of several types of interneurons. Among the interneurons are a group of cells that express tyrosine hydroxylase ... -
Venom-derived peptide modulators of cation-selective channels : friend, foe or frenemy
(2019)Ion channels play a key role in our body to regulate homeostasis and conduct electrical signals. With the help of advances in structural biology, as well as the discovery of numerous channel modulators derived from animal ...
