Recent Submissions

  • Localization of α 2u-globulin in the acinar cells of preputial gland, and confirmation of its binding with farnesol, a putative pheromone, in field rat (Millardia meltada) 

    Rajamanickam, Ramachandran; Shanmugam, Achiraman; Thangavel, Rajagopal; Devaraj, Sankarganesh; Soundararajan, Kamalakkannan; Ponnirul, Ponmanickam; Ramalingam, Rajkumar; Ganesan, Ramya Vaideki; Parasuraman, Padmanabhan; Govindaraju, Archunan (2018)
    Pheromones, low molecular weight chemical entities that bind to pheromone carrier proteins, are chemical signals that play an important role in the communication system in animals. This has been rather fairly well-studied ...
  • Evaluation of flicker induced hyperemia in the retina and optic nerve head measured by Laser Speckle Flowgraphy 

    Fondi, Klemens; Bata, Ahmed M.; Luft, Nikolaus; Witkowska, Katarzyna J.; Werkmeister, René M.; Schmidl, Doreen; Bolz, Matthias; Schmetterer, Leopold; Garhöfer, Gerhard (2018)
    Purpose: The coupling between neural activity and blood flow is a physiological key principle of ocular blood flow regulation. The current study was performed to investigate whether Laser speckle flowgraphy (LSFG), a ...
  • Early developmental perturbations in a human stem cell model of MODY5/HNF1B pancreatic hypoplasia 

    Teo, Adrian Kee Keong; Lau, Hwee Hui; Valdez, Ivan Achel; Dirice, Ercument; Tjora, Erling; Raeder, Helge; Kulkarni, Rohit N. (2016)
    Patients with an HNF1BS148L/+ mutation (MODY5) typically exhibit pancreatic hypoplasia. However, the molecular mechanisms are unknown due to inaccessibility of patient material and because mouse models do not fully ...
  • Hyperlipidemia, statin use and dengue severity 

    Chia, Po Ying; Htun, Htet Lin; Ling, Wei Ping; Leo, Yee Sin; Yeo, Tsin Wen; Lye, David Chien Boon (2018)
    Multiple in vitro and mice model studies suggest statins may attenuate dengue severity. However, little is known about statin use and dengue severity in adult dengue patients with hyperlipidemia. We conducted a retrospective ...
  • Asymmetric dimethylarginine in adult falciparum malaria: relationships with disease severity, antimalarial treatment, hemolysis, and inflammation 

    Barber, Bridget E.; William, Timothy; Grigg, Matthew J.; Parameswaran, Uma; Piera, Kim A.; Yeo, Tsin Wen; Anstey, Nicholas M. (2016)
    Background: Endothelial nitric oxide (NO) bioavailability is impaired in severe falciparum malaria (SM). Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase (NOS), contributes to endothelial dysfunction ...
  • Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise 

    Chooi, Yu Chung; Ding, Cherlyn; Chan, Zhiling; Lo, Jezebel; Choo, John; Ding, Benjamin T. K.; Leow, Melvin Khee-Shing; Magkos, Faidon (2018)
    Weight loss, induced by chronic energy deficit, improves the blood lipid profile. However, the effects of an acute negative energy balance and the comparative efficacy of diet and exercise are not well-established. We ...
  • Structural complexity of filaments formed from the actin and tubulin folds 

    Jiang, Shimin; Ghoshdastider, Umesh; Narita, Akihiro; Popp, David; Robinson, Robert Charles (2016)
    From yeast to man, an evolutionary distance of 1.3 billion years, the F-actin filament structure has been conserved largely in line with the 94% sequence identity. The situation is entirely different in bacteria. In ...
  • Mothers after gestational diabetes in Australia (MAGDA): a randomised controlled trial of a postnatal diabetes prevention program 

    O’Reilly, Sharleen L.; Dunbar, James A.; Versace, Vincent; Janus, Edward; Best, James D.; Carter, Rob; Oats, Jeremy J. N.; Skinner, Timothy; Ackland, Michael; Phillips, Paddy A.; Ebeling, Peter R.; Reynolds, John; Shih, Sophy T. F.; Hagger, Virginia; Coates, Michael; Wildey, Carol (2016)
    Background: Gestational diabetes mellitus (GDM) is an increasingly prevalent risk factor for type 2 diabetes. We evaluated the effectiveness of a group-based lifestyle modification program in mothers with prior GDM within ...
  • Preventing delayed diagnosis of cancer: clinicians’ views on main problems and solutions 

    Car, Lorainne Tudor; Papachristou, Nikolaos; Urch, Catherine; Majeed, Azeem; El–Khatib, Mona; Aylin, Paul; Atun, Rifat; Car, Josip; Vincent, Charles (2016)
    Background Delayed diagnosis is a major contributing factor to the UK’s lower cancer survival compared to many European countries. In the UK, there is a significant national variation in early cancer diagnosis. Healthcare ...
  • The significance of prolonged and saddleback fever in hospitalised adult dengue 

    Ng, Deborah HL; Wong, Joshua GX; Thein, Tun-Linn; Leo, Yee-Sin; Lye, David C. (2016)
    Dengue fever is gaining importance in Singapore with an increase in the number of cases and mortality in recent years. Although prolonged and saddleback fever have been reported in dengue fever, there are no specific studies ...
  • Ocular blood flow measurements in healthy white subjects using laser speckle flowgraphy 

    Luft, Nikolaus; Wozniak, Piotr A.; Aschinger, Gerold C.; Fondi, Klemens; Bata, Ahmed M.; Werkmeister, René M.; Schmidl, Doreen; Witkowska, Katarzyna J.; Bolz, Matthias; Garhöfer, Gerhard; Schmetterer, Leopold (2016)
    Purpose: To assess the feasibility and reliability of Laser Speckle Flowgraphy (LSFG) to measure ocular perfusion in a sample of healthy white subjects and to elucidate the age-dependence of the parameters obtained. Methods: ...
  • Editorial : imaging synapse structure and function 

    Augustine, George James; Fivaz, Marc (2016)
    These are the glory days for imaging synapse structure and function. Thanks to recent advances in both optical and electron microscopy, it is now possible to image individual synapses with unprecedented spatial and temporal ...
  • Five-Year clinical trial on Atropine for the Treatment of Myopia 2 

    Chia, Audrey; Lu, Qing-Shu; Tan, Donald (2016)
    Purpose: To compare the safety and efficacy of different concentrations of atropine eyedrops in controlling myopia progression over 5 years. Design: Randomized, double-masked clinical trial. Participants: A total of 400 ...
  • The action of mimetic peptides on connexins protects fibroblasts from the negative effects of ischemia reperfusion 

    Glass, Beverley J.; Hu, Rebecca G.; Phillips, Anthony R. J.; Becker, David Laurence (2015)
    Connexins have been proposed as a target for therapeutic treatment of a variety of conditions. The main approaches have been by antisense or small peptides specific against connexins. Some of these peptides enhance ...
  • LFA-1/ICAM-1 ligation in human T cells promotes Th1 polarization through a GSK3β signaling–dependent notch pathway 

    Verma, Navin Kumar; Mobashar Hussain Urf Turabe Fazil; Ong, Seow Theng; Chalasani, Madhavi Latha Somaraju; Low, Jian Hui; Kottaiswamy, Amuthavalli; Praseetha P; Kizhakeyil, Atish; Kumar, Sunil; Panda, Aditya K.; Freeley, Michael; Smith, Sinead M.; Boehm, Bernhard O.; Kelleher, Dermot (2016)
    In this study, we report that the integrin LFA-1 cross-linking with its ligand ICAM-1 in human PBMCs or CD4+ T cells promotes Th1 polarization by upregulating IFN-γ secretion and T-bet expression. LFA-1 stimulation in ...
  • Systematic evaluation of genes and genetic variants associated with type 1 diabetes susceptibility 

    Ram, Ramesh; Mehta, Munish; Nguyen, Quang T.; Larma, Irma; Boehm, Bernhard Otto; Pociot, Flemming; Concannon, Patrick; Morahan, Grant (2016)
    Genome-wide association studies have found >60 loci that confer genetic susceptibility to type 1 diabetes (T1D). Many of these are defined only by anonymous single nucleotide polymorphisms: the underlying causative genes, ...
  • Germline mutations in cancer predisposition genes are frequent in sporadic sarcomas 

    Chan, Sock Hoai; Lim, Weng Khong; Nur Diana Binte Ishak; Li, Shao-Tzu; Goh, Wei Lin; Tan, Gek San; Lim, Kiat Hon; Teo, Melissa; Ng, Cedric Chuan Young; Malik, Simeen; Tan, Mann Hong; Teh, Jonathan Yi Hui; Chin, Francis Kuok Choon; Kesavan, Sittampalam; Selvarajan, Sathiyamoorthy; Tan, Patrick; Teh, Bin Tean; Soo, Khee Chee; Mohamad Farid; Quek, Richard; Ngeow, Joanne (2017)
    Associations of sarcoma with inherited cancer syndromes implicate genetic predisposition in sarcoma development. However, due to the apparently sporadic nature of sarcomas, little attention has been paid to the role genetic ...
  • Photoacoustic imaging of lamina cribrosa microcapillaries in porcine eyes 

    Chuangsuwanich, Thanadet; Moothanchery, Mohesh; Tsz, Alvan Chung Yan; Schmetterer, Leopold; Girard, Michaël J. A.; Pramanik, Manojit (2018)
    Due to the embedded nature of the lamina cribrosa (LC) microcapillary network, conventional imaging techniques have failed to obtain the high-resolution images needed to assess the perfusion state of the LC. In this study, ...
  • Dihydrofolate-reductase mutations in Plasmodium knowlesi appear unrelated to selective drug pressure from putative human-to-human transmission in Sabah, Malaysia 

    Grigg, Matthew J.; Barber, Bridget E.; Marfurt, Jutta; Imwong, Mallika; William, Timothy; Bird, Elspeth; Piera, Kim A.; Aziz, Ammar; Boonyuen, Usa; Drakeley, Christopher J.; Cox, Jonathan; White, Nicholas J.; Cheng, Qin; Yeo, Tsin Wen; Auburn, Sarah; Anstey, Nicholas M. (2016)
    Background: Malaria caused by zoonotic Plasmodium knowlesi is an emerging threat in Eastern Malaysia. Despite demonstrated vector competency, it is unknown whether human-to-human (H-H) transmission is occurring naturally. ...
  • 3D neural tissue models : from spheroids to bioprinting 

    Zhuang, Pei; Sun, Alfred Xuyang; An, Jia; Chua, Chee Kai; Chew, Sing Yian (2018)
    Three-dimensional (3D) in vitro neural tissue models provide a better recapitulation of in vivo cell-cell and cell-extracellular matrix interactions than conventional two-dimensional (2D) cultures. Therefore, the former ...

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