RSS 1.0LKCMedicine Journal Articles
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Localization of α 2u-globulin in the acinar cells of preputial gland, and confirmation of its binding with farnesol, a putative pheromone, in field rat (Millardia meltada)
(2018)Pheromones, low molecular weight chemical entities that bind to pheromone carrier proteins, are chemical signals that play an important role in the communication system in animals. This has been rather fairly well-studied ... -
Evaluation of flicker induced hyperemia in the retina and optic nerve head measured by Laser Speckle Flowgraphy
(2018)Purpose: The coupling between neural activity and blood flow is a physiological key principle of ocular blood flow regulation. The current study was performed to investigate whether Laser speckle flowgraphy (LSFG), a ... -
Early developmental perturbations in a human stem cell model of MODY5/HNF1B pancreatic hypoplasia
(2016)Patients with an HNF1BS148L/+ mutation (MODY5) typically exhibit pancreatic hypoplasia. However, the molecular mechanisms are unknown due to inaccessibility of patient material and because mouse models do not fully ... -
Hyperlipidemia, statin use and dengue severity
(2018)Multiple in vitro and mice model studies suggest statins may attenuate dengue severity. However, little is known about statin use and dengue severity in adult dengue patients with hyperlipidemia. We conducted a retrospective ... -
Asymmetric dimethylarginine in adult falciparum malaria: relationships with disease severity, antimalarial treatment, hemolysis, and inflammation
(2016)Background: Endothelial nitric oxide (NO) bioavailability is impaired in severe falciparum malaria (SM). Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase (NOS), contributes to endothelial dysfunction ... -
Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise
(2018)Weight loss, induced by chronic energy deficit, improves the blood lipid profile. However, the effects of an acute negative energy balance and the comparative efficacy of diet and exercise are not well-established. We ... -
Structural complexity of filaments formed from the actin and tubulin folds
(2016)From yeast to man, an evolutionary distance of 1.3 billion years, the F-actin filament structure has been conserved largely in line with the 94% sequence identity. The situation is entirely different in bacteria. In ... -
Mothers after gestational diabetes in Australia (MAGDA): a randomised controlled trial of a postnatal diabetes prevention program
(2016)Background: Gestational diabetes mellitus (GDM) is an increasingly prevalent risk factor for type 2 diabetes. We evaluated the effectiveness of a group-based lifestyle modification program in mothers with prior GDM within ... -
Preventing delayed diagnosis of cancer: clinicians’ views on main problems and solutions
(2016)Background Delayed diagnosis is a major contributing factor to the UK’s lower cancer survival compared to many European countries. In the UK, there is a significant national variation in early cancer diagnosis. Healthcare ... -
The significance of prolonged and saddleback fever in hospitalised adult dengue
(2016)Dengue fever is gaining importance in Singapore with an increase in the number of cases and mortality in recent years. Although prolonged and saddleback fever have been reported in dengue fever, there are no specific studies ... -
Ocular blood flow measurements in healthy white subjects using laser speckle flowgraphy
(2016)Purpose: To assess the feasibility and reliability of Laser Speckle Flowgraphy (LSFG) to measure ocular perfusion in a sample of healthy white subjects and to elucidate the age-dependence of the parameters obtained. Methods: ... -
Editorial : imaging synapse structure and function
(2016)These are the glory days for imaging synapse structure and function. Thanks to recent advances in both optical and electron microscopy, it is now possible to image individual synapses with unprecedented spatial and temporal ... -
Five-Year clinical trial on Atropine for the Treatment of Myopia 2
(2016)Purpose: To compare the safety and efficacy of different concentrations of atropine eyedrops in controlling myopia progression over 5 years. Design: Randomized, double-masked clinical trial. Participants: A total of 400 ... -
The action of mimetic peptides on connexins protects fibroblasts from the negative effects of ischemia reperfusion
(2015)Connexins have been proposed as a target for therapeutic treatment of a variety of conditions. The main approaches have been by antisense or small peptides specific against connexins. Some of these peptides enhance ... -
LFA-1/ICAM-1 ligation in human T cells promotes Th1 polarization through a GSK3β signaling–dependent notch pathway
(2016)In this study, we report that the integrin LFA-1 cross-linking with its ligand ICAM-1 in human PBMCs or CD4+ T cells promotes Th1 polarization by upregulating IFN-γ secretion and T-bet expression. LFA-1 stimulation in ... -
Systematic evaluation of genes and genetic variants associated with type 1 diabetes susceptibility
(2016)Genome-wide association studies have found >60 loci that confer genetic susceptibility to type 1 diabetes (T1D). Many of these are defined only by anonymous single nucleotide polymorphisms: the underlying causative genes, ... -
Germline mutations in cancer predisposition genes are frequent in sporadic sarcomas
(2017)Associations of sarcoma with inherited cancer syndromes implicate genetic predisposition in sarcoma development. However, due to the apparently sporadic nature of sarcomas, little attention has been paid to the role genetic ... -
Photoacoustic imaging of lamina cribrosa microcapillaries in porcine eyes
(2018)Due to the embedded nature of the lamina cribrosa (LC) microcapillary network, conventional imaging techniques have failed to obtain the high-resolution images needed to assess the perfusion state of the LC. In this study, ... -
Dihydrofolate-reductase mutations in Plasmodium knowlesi appear unrelated to selective drug pressure from putative human-to-human transmission in Sabah, Malaysia
(2016)Background: Malaria caused by zoonotic Plasmodium knowlesi is an emerging threat in Eastern Malaysia. Despite demonstrated vector competency, it is unknown whether human-to-human (H-H) transmission is occurring naturally. ... -
3D neural tissue models : from spheroids to bioprinting
(2018)Three-dimensional (3D) in vitro neural tissue models provide a better recapitulation of in vivo cell-cell and cell-extracellular matrix interactions than conventional two-dimensional (2D) cultures. Therefore, the former ...
