• Regulation of choroidal blood flow during isometric exercise at different levels of intraocular pressure 

  Popa-Cherecheanu, Alina; Schmidl, Doreen; Werkmeister, René M.; Chua, Jacqueline; Garhöfer, Gerhard; Schmetterer, Leopold (2019)

  Purpose: There is evidence that choroidal blood flow (ChBF) is regulated in a complex way during changes in ocular perfusion pressure (OPP). We hypothesized that ChBF regulates better in response to changes in mean arterial ...

• Inducing ischemia-reperfusion injury in the mouse ear skin for intravital multiphoton imaging of immune responses 

  Goh, Chi Ching; Li, Jackson LiangYao; Becker, David; Weninger, Wolfgang; Angeli, Veronique; Ng, Lai Guan (2016)

  Ischemia-reperfusion injury (IRI) occurs when there is transient hypoxia due to the obstruction of blood flow (ischemia) followed by a subsequent re-oxygenation of the tissues (reperfusion). In the skin, ischemia-reperfusion ...

• Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia : in vivo therapeutic efficacy and kelch13 molecular marker surveillance 

  Grigg, Matthew J.; William, Timothy; Piera, Kim A.; Rajahram, Giri S.; Jelip, Jenarun; Aziz, Ammar; Menon, Jayaram; Marfurt, Jutta; Price, Ric N.; Auburn, Sarah; Barber, Bridget E.; Yeo, Tsin Wen; Anstey, Nicholas M. (2018)

  Background:Spreading Plasmodium falciparum artemisinin drug resistance threatens global malaria public health gains. Limited data exist to define the extent of P. falciparum artemisinin resistance southeast of the Greater ...

• Clinical instructors’ perceptions of virtual reality in health professionals’ cardiopulmonary resuscitation education 

  Wong, Marie Ann Mae En; Chue, Shien; Jong, Michelle; Ho, Benny Wye Kei; Zary, Nabil (2018)

  Objectives: Cardiopulmonary resuscitation (CPR) is lifesaving. Yet, cardiac arrest survival remains low despite CPR intervention. Education has been highlighted as a strategy to overcome this issue. Virtual Reality technology ...

• Return on investment in blended advanced cardiac life support training compared to face-to-face training in Singapore 

  George, Pradeep Paul; Ooi, Chee Kheong; Leong, Edwin; Jarbrink, Krister; Car, Josip; Lockwood, Craig (2018)

  Background: Internet adoption during the past decade has provided opportunities for innovation in advanced cardiac life support (ACLS) training. With pressure on budgets across health care systems, there is a need for more ...

• The role of primary care in the dynamics of a health system 

  Matchar, David Bruce; Car, Josip; Koh, Gerald Choon Huat (2018)

  This paper explain the role of primary care in the dynamics of a health system.

• Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents 

  Yuan, Mingjun; Chua, Song Lin; Liu, Yang; Drautz-Moses, Daniela Isabel; Yam, Joey Kuok Hoong; Aung, Thet Tun; Beuerman, Roger W.; Salido, May Margarette Santillan; Schuster, Stephan Christoph; Tan, Choon-Hong; Givskov, Michael; Yang, Liang; Nielsen, Thomas Eiland (2018)

  Antibiotic resistance threatens effective treatment of microbial infections globally. This situation has spurred the hunt for new antimicrobial compounds in both academia and the pharmaceutical industry. Here, we report ...

• Genetic polymorphism and natural selection in the C-terminal 42 kDa region of merozoite surface protein-1 (MSP-1) among Plasmodium knowlesi samples from Malaysia 

  Yap, Nan Jiun; Vythilingam, Indra; Hoh, Boon Peng; Goh, Xiang Ting; Muslim, Azdayanti; Ngui, Romano; Rajoo, Yamuna; Choy, Seow Huey; William, Timothy; Yeo, Tsin Wen; Lim, Yvonne Ai-Lian (2018)

  Background: The merozoite surface protein-1 (MSP-1) gene encodes for a leading malaria vaccine candidate antigen. However, its extensive polymorphic nature represents a major obstacle to the development of a protective ...

• High yield of HIV testing in dengue-like febrile illness in Singapore 

  Verrall, Ayesha J.; Lye, David Chienboon; Pada, Surinder; Smitasin, Nares; Lee, Chun-Kiat; Khoo, Mui-Joo; Koay, Evelyn S.; Leo, Yee-Sin; Fisher, Dale A.; Archuleta, Sophia (2018)

  Where dengue virus infections are endemic, acute febrile illness is often managed as dengue fever (DF) without diagnostic testing. In a prospective study of 140 patients with clinical features of DF, 3 (2.1%) had acute HIV ...

• Non‐clinical interventions for reducing unnecessary caesarean section 

  Chen, Innie; Opiyo, Newton; Tavender, Emma; Mortazhejri, Sameh; Rader, Tamara; Petkovic, Jennifer; Yogasingam, Sharlini; Taljaard, Monica; Agarwal, Sugandha; Laopaiboon, Malinee; Wasiak, Jason; Khunpradit, Suthit; Lumbiganon, Pisake; Gruen, Russell Lindsay; Betran, Ana Pilar (2018)

  Background: Caesarean section rates are increasing globally. The factors contributing to this increase are complex, and identifying interventions to address them is challenging. Non‐clinical interventions are applied ...

• Antimicrobial quaternary ammonium organosilane cross-linked nanofibrous collagen scaffolds for tissue engineering 

  Dhand, Chetna; Balakrishnan, Yamini; Ong, Seow Theng; Dwivedi, Neeraj; Venugopal, Jayarama R.; Harini, Sriram; Leung, Chak Ming; Low, Kenny Zhi Wei; Loh, Xian Jun; Beuerman, Roger W.; Ramakrishna, Seeram; Verma, Navin Kumar; Lakshminarayanan, Rajamani (2018)

  Introduction: In search for cross-linkers with multifunctional characteristics, the present work investigated the utility of quaternary ammonium organosilane (QOS) as a potential cross-linker for electrospun collagen ...

• Levels of serum brain-derived neurotropic factor in individuals at ultra-high risk for psychosis—findings from the longitudinal youth at risk study (LYRIKS) 

  Yee, Jie Yin; Lee, Tih-Shih; Lee, Jimmy (2018)

  Background:Identifying biomarkers to enrich prognostication and risk predictions in individuals at high risk of developing psychosis will enable stratified early intervention efforts. Brain-derived neurotrophic factor has ...

• Theranostic applications of nanoparticles in neurodegenerative disorders 

  Ramanathan, Sahana; Archunan, Govindaraju; Sivakumar, Muthusamy; Selvan, Subramanian Tamil; Fred, A. Lenin; Kumar, Sundramurthy; Gulyás, Balázs; Padmanabhan, Parasuraman (2018)

  The preeminent treatments for neurodegenerative disease are often unavailable due to the poor accessibility of therapeutic drugs. Moreover, the blood–brain barrier (BBB) effectively blocks the transfer of cells, particles ...

• Economic evaluation of the NET intervention versus guideline dissemination for management of mild head injury in hospital emergency departments 

  Mortimer, Duncan; Bosch, Marije; Mckenzie, Joanne E.; Turner, Simon; Chau, Marisa; Ponsford, Jennie L.; Knott, Jonathan C.; Gruen, Russell Lindsay; Green, Sally E. (2018)

  Background:Evidence-based guidelines for the management of mild traumatic brain injury (mTBI) in the emergency department (ED) are now widely available, and yet, clinical practice remains inconsistent with the guidelines. ...

• MOOC learners’ engagement with two variants of virtual patients : a randomised trial 

  Stathakarou, Natalia; Scully, Marcel Leon; Kononowicz, Andrzej A.; Henningsohn, Lars; Zary, Nabil; McGrath, Cormac (2018)

  Introduction: Massive Open Online Courses (MOOCs) are an increasingly popular form of education in health professional education. VPs have been introduced in MOOCs to increase interactivity. There is a lack of research in ...

• Targeting metabolic flexibility via angiopoietin-like 4 protein sensitizes metastatic cancer cells to chemotherapy drugs 

  Lim, Maegan Miang Kee; Wee, Jonathan Wei Kiat; Soong, Jen Chi; Chua, Damien; Tan, Wei Ren; Lizwan, Marco; Li, Yinliang; Teo, Ziqiang; Goh, Wilson Wen Bin; Zhu, Pengcheng; Tan, Nguan Soon (2018)

  Overcoming multidrug resistance has always been a major challenge in cancer treatment. Recent evidence suggested epithelial-mesenchymal transition plays a role in MDR, but the mechanism behind this link remains unclear. ...

• The currency, completeness and quality of systematic reviews of acute management of moderate to severe traumatic brain injury : a comprehensive evidence map 

  Synnot, Anneliese; Bragge, Peter; Lunny, Carole; Menon, David; Clavisi, Ornella; Pattuwage, Loyal; Volovici, Victor; Mondello, Stefania; Cnossen, Maryse C.; Donoghue, Emma; Gruen, Russell Lindsay; Maas, Andrew (2018)

  Objective: To appraise the currency, completeness and quality of evidence from systematic reviews (SRs) of acute management of moderate to severe traumatic brain injury (TBI). Methods: We conducted comprehensive searches ...

• Cross-reactivity and anti-viral function of dengue capsid and NS3-specific memory T cells toward Zika virus 

  Lim, Mei Qiu; Kumaran, Emmanuelle A. P.; Tan, Hwee Cheng; Lye, David Chienboon; Leo, Yee Sin; Ooi, Eng Eong; MacAry, Paul A.; Bertoletti, Antonio; Rivino, Laura (2018)

  Zika virus (ZIKV), a flavivirus with homology to dengue virus (DENV), is spreading to areas of DENV hyper-endemicity. Heterologous T cell immunity, whereby virus-specific memory T cells are activated by variant peptides ...

• PET-MR and SPECT-MR multimodality probes: development and challenges 

  Yang, Chang-Tong; Ghosh, Krishna Kanta; Padmanabhan, Parasuraman; Langer, Oliver; Liu, Jiang; Eng, David Ng Chee; Halldin, Christer; Gulyás, Balázs (2018)

  Positron emission tomography (PET)-magnetic resonance (MR) or single photon emission computed tomography (SPECT)-MR hybrid imaging is being used in daily clinical practice. Due to its advantages over stand-alone PET, SPECT ...

• Automated telephone communication systems for preventive healthcare and management of long‐term conditions 

  Posadzki, Pawel; Mastellos, Nikolaos; Ryan, Rebecca; Gunn, Laura H.; Felix, Lambert M.; Pappas, Yannis; Gagnon, Marie-Pierre; Julious, Steven A.; Xiang, Liming; Oldenburg, Brian; Car, Josip (2016)

  Background: Automated telephone communication systems (ATCS) can deliver voice messages and collect health‐related information from patients using either their telephone's touch‐tone keypad or voice recognition software. ...

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