RSS 1.0LKCMedicine Journal Articles
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KIAA1109 variants are associated with a severe disorder of brain development and arthrogryposis
(2017)Whole-exome and targeted sequencing of 13 individuals from 10 unrelated families with overlapping clinical manifestations identified loss-of-function and missense variants in KIAA1109 allowing delineation of an autosomal-recessive ... -
Novel mutation G324C in WNT1 mapped in a large Pakistani family with severe recessively inherited Osteogenesis Imperfecta
(2018)Introduction: Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous disease with skeletal fragility and variable extra-skeletal manifestations. To date several point mutations in 18 different genes ... -
Modulation of cell-cell interactions for neural tissue engineering : potential therapeutic applications of cell adhesion molecules in nerve regeneration
(2019)Neural tissue engineering holds great promise in repairing damaged nerve tissues. However, despite the promising results in regenerating the injured nervous system, tissue engineering approaches are still insufficient to ... -
Quantitative analysis of choriocapillaris in non-human primates using swept-source optical coherence tomography angiography (SS-OCTA)
(2019)The choriocapillaris is a unique vascular plexus located posterior to the retinal pigment epithelium. In recent years, there is an increasing interest in the examination of the interrelationship between the choriocapillaris ... -
CorneaNet : fast segmentation of cornea OCT scans of healthy and keratoconic eyes using deep learning
(2019)Deep learning has dramatically improved object recognition, speech recognition, medical image analysis and many other fields. Optical coherence tomography (OCT) has become a standard of care imaging modality for ophthalmology. ... -
Oncogenic activation of the stat3 pathway drives pd-l1 expression in natural killer/t-cell lymphoma
(2018)Mature T-cell lymphomas, including peripheral T-cell lymphoma (PTCL) and extranodal NK/T-cell lymphoma (NKTL), represent a heterogeneous group of non-Hodgkin lymphomas with dismal outcomes and limited treatment options. ... -
Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis
(2018)A wealth of scientific and clinical evidence during the past few years has lent credence to the idea that key components of the host immune effector mechanisms can be targeted to boost current tuberculosis (TB) treatment ... -
Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery
(2018)Eye diseases and injuries impose a significant clinical problem worldwide. Safe and effective ocular drug delivery is, however, challenging due to the presence of ocular barriers. Here we report a strategy using an eye ... -
Regulation of choroidal blood flow during isometric exercise at different levels of intraocular pressure
(2019)Purpose: There is evidence that choroidal blood flow (ChBF) is regulated in a complex way during changes in ocular perfusion pressure (OPP). We hypothesized that ChBF regulates better in response to changes in mean arterial ... -
Inducing ischemia-reperfusion injury in the mouse ear skin for intravital multiphoton imaging of immune responses
(2016)Ischemia-reperfusion injury (IRI) occurs when there is transient hypoxia due to the obstruction of blood flow (ischemia) followed by a subsequent re-oxygenation of the tissues (reperfusion). In the skin, ischemia-reperfusion ... -
Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia : in vivo therapeutic efficacy and kelch13 molecular marker surveillance
(2018)Background:Spreading Plasmodium falciparum artemisinin drug resistance threatens global malaria public health gains. Limited data exist to define the extent of P. falciparum artemisinin resistance southeast of the Greater ... -
Clinical instructors’ perceptions of virtual reality in health professionals’ cardiopulmonary resuscitation education
(2018)Objectives: Cardiopulmonary resuscitation (CPR) is lifesaving. Yet, cardiac arrest survival remains low despite CPR intervention. Education has been highlighted as a strategy to overcome this issue. Virtual Reality technology ... -
Return on investment in blended advanced cardiac life support training compared to face-to-face training in Singapore
(2018)Background: Internet adoption during the past decade has provided opportunities for innovation in advanced cardiac life support (ACLS) training. With pressure on budgets across health care systems, there is a need for more ... -
The role of primary care in the dynamics of a health system
(2018)This paper explain the role of primary care in the dynamics of a health system. -
Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents
(2018)Antibiotic resistance threatens effective treatment of microbial infections globally. This situation has spurred the hunt for new antimicrobial compounds in both academia and the pharmaceutical industry. Here, we report ... -
Genetic polymorphism and natural selection in the C-terminal 42 kDa region of merozoite surface protein-1 (MSP-1) among Plasmodium knowlesi samples from Malaysia
(2018)Background: The merozoite surface protein-1 (MSP-1) gene encodes for a leading malaria vaccine candidate antigen. However, its extensive polymorphic nature represents a major obstacle to the development of a protective ... -
High yield of HIV testing in dengue-like febrile illness in Singapore
(2018)Where dengue virus infections are endemic, acute febrile illness is often managed as dengue fever (DF) without diagnostic testing. In a prospective study of 140 patients with clinical features of DF, 3 (2.1%) had acute HIV ... -
Non‐clinical interventions for reducing unnecessary caesarean section
(2018)Background: Caesarean section rates are increasing globally. The factors contributing to this increase are complex, and identifying interventions to address them is challenging. Non‐clinical interventions are applied ... -
Antimicrobial quaternary ammonium organosilane cross-linked nanofibrous collagen scaffolds for tissue engineering
(2018)Introduction: In search for cross-linkers with multifunctional characteristics, the present work investigated the utility of quaternary ammonium organosilane (QOS) as a potential cross-linker for electrospun collagen ... -
Levels of serum brain-derived neurotropic factor in individuals at ultra-high risk for psychosis—findings from the longitudinal youth at risk study (LYRIKS)
(2018)Background:Identifying biomarkers to enrich prognostication and risk predictions in individuals at high risk of developing psychosis will enable stratified early intervention efforts. Brain-derived neurotrophic factor has ...
