Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/103661
Title: | A generic micropatterning platform to direct human mesenchymal stem cells from different origins towards myogenic differentiation | Authors: | Tan, Lay Poh Yu, Ting Chua, Chee Kai Tay, Chor Yong Wen, Feng Yu, Haiyang Chan, Jerry Kok Yen Chong, Mark Seow Khoon Leong, David Tai Wei |
Keywords: | DRNTU::Engineering::Chemical engineering::Biochemical engineering | Issue Date: | 2013 | Source: | Yu, T., Chua, C. K., Tay, C. Y., Wen, F., Yu, H., Chan, J. K. Y., et al. (2013). A generic micropatterning platform to direct human mesenchymal stem cells from different origins towards myogenic differentiation. Macromolecular bioscience, 13(6), 799-807. | Series/Report no.: | Macromolecular bioscience | Abstract: | Human mesenchymal stem cells (MSCs) derived from various origins show varied differentiation capability. Recent work shows that cell shape manipulation via micropatterning can modulate the differentiation of bone-marrow-derived MSCs. Herein, the effect of micropatterning on the myogenesis of MSCs isolated from three different sources (bone marrow, fetal tissue, and adipose) is reported. All the well-aligned cells, regardless of source, predominantly commit to myogenic lineage, as shown by the significant upregulation of myogenic gene markers and positive myosin heavy chain staining. It is demonstrated that our novel micropattern can be used as a generic platform for inducing myogenesis of MSCs from different sources and may also have the potential to be extended to induce other lineage commitment. | URI: | https://hdl.handle.net/10356/103661 http://hdl.handle.net/10220/16726 |
ISSN: | 1616-5187 | DOI: | 10.1002/mabi.201200481 | Schools: | School of Chemical and Biomedical Engineering School of Materials Science & Engineering School of Mechanical and Aerospace Engineering |
Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | MAE Journal Articles MSE Journal Articles SCBE Journal Articles |
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