Anti-HIV-1 nanotherapeutics : promises and challenges for the future
Mahajan, Supriya D.
Reynolds, Jessica L.
Nair, Bindukumar B.
Sykes, Donald E.
Prasad, Paras N.
Schwartz, Stanley A.
Date of Issue2012
School of Electrical and Electronic Engineering
The advent of highly active antiretroviral therapy (HAART) has significantly improved the prognosis for human immunodeficiency virus (HIV)-infected patients, however the adverse side effects associated with prolonged HAART therapy use continue. Although systemic viral load can be undetectable, the virus remains sequestered in anatomically privileged sites within the body. Nanotechnology-based delivery systems are being developed to target the virus within different tissue compartments and are being evaluated for their safety and efficacy. The current review outlines the various nanomaterials that are becoming increasingly used in biomedical applications by virtue of their robustness, safety, multimodality, and multifunctionality. Nanotechnology can revolutionize the field of HIV medicine by not only improving diagnosis, but also by improving delivery of antiretrovirals to targeted regions in the body and by significantly enhancing the efficacy of the currently available antiretroviral medications.
DRNTU::Engineering::Electrical and electronic engineering
International journal of nanomedicine
© 2012 Mahajan et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.