dc.contributor.authorThole, Sebastian
dc.contributor.authorKalhoefer, Daniela
dc.contributor.authorVoget, Sonja
dc.contributor.authorBerger, Martine
dc.contributor.authorEngelhardt, Tim
dc.contributor.authorLiesegang, Heiko
dc.contributor.authorWollherr, Antje
dc.contributor.authorKjelleberg, Staffan
dc.contributor.authorDaniel, Rolf
dc.contributor.authorSimon, Meinhard
dc.contributor.authorThomas, Torsten
dc.contributor.authorBrinkhoff, Thorsten
dc.date.accessioned2013-10-25T03:16:37Z
dc.date.available2013-10-25T03:16:37Z
dc.date.copyright2012en_US
dc.date.issued2012
dc.identifier.citationThole, S., Kalhoefer, D., Voget, S., Berger, M., Engelhardt, T., Liesegang, H., et al. (2012). Phaeobacter gallaeciensis genomes from globally opposite locations reveal high similarity of adaptation to surface life. The ISME Journal, 6, 2229-2244.en_US
dc.identifier.urihttp://hdl.handle.net/10220/16900
dc.description.abstractPhaeobacter gallaeciensis, a member of the abundant marine Roseobacter clade, is known to be an effective colonizer of biotic and abiotic marine surfaces. Production of the antibiotic tropodithietic acid (TDA) makes P. gallaeciensis a strong antagonist of many bacteria, including fish and mollusc pathogens. In addition to TDA, several other secondary metabolites are produced, allowing the mutualistic bacterium to also act as an opportunistic pathogen. Here we provide the manually annotated genome sequences of the P. gallaeciensis strains DSM 17395 and 2.10, isolated at the Atlantic coast of north western Spain and near Sydney, Australia, respectively. Despite their isolation sites from the two different hemispheres, the genome comparison demonstrated a surprisingly high level of synteny (only 3% nucleotide dissimilarity and 88% and 93% shared genes). Minor differences in the genomes result from horizontal gene transfer and phage infection. Comparison of the P. gallaeciensis genomes with those of other roseobacters revealed unique genomic traits, including the production of iron-scavenging siderophores. Experiments supported the predicted capacity of both strains to grow on various algal osmolytes. Transposon mutagenesis was used to expand the current knowledge on the TDA biosynthesis pathway in strain DSM 17395. This first comparative genomic analysis of finished genomes of two closely related strains belonging to one species of the Roseobacter clade revealed features that provide competitive advantages and facilitate surface attachment and interaction with eukaryotic hosts.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesThe ISME journalen_US
dc.rights© 2012 International Society for Microbial Ecology.en_US
dc.subjectDRNTU::Science::Biological sciences
dc.titlePhaeobacter gallaeciensis genomes from globally opposite locations reveal high similarity of adaptation to surface lifeen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1038/ismej.2012.62


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