dc.contributor.authorLee, Wei Li
dc.contributor.authorShi, Wenxiong
dc.contributor.authorLow, Zheng Yang
dc.contributor.authorLi, Shuzhou
dc.contributor.authorLoo, Say Chye Joachim
dc.identifier.citationLee, W. L., Shi, W., Low, Z. Y., Li, S., & Loo, S. C. J. (2012). Modeling of drug release from biodegradable triple-layered microparticles. Journal of biomedical materials research part A, 100A(12), 3353-3362.en_US
dc.description.abstractNumerous models that predict drug release from nonerodible reservoir-membrane sphere systems have been presented. Most of these models cater only to a phase of drug release from a constant reservoir. All these models, however, are not applicable to drug release from biodegradable triple-layered microparticle system, in which the drug-loaded core (reservoir) is surrounded by nondrug holding outer layers (membrane). In this article, a mathematical model was developed for ibuprofen release from degradable triple-layered microparticles made of poly(D,L-lactide-co-glycolide, 50:50) (PLGA), poly(L-lactide) (PLLA), and poly(ethylene-co-vinyl acetate, 40 wt % vinyl acetate) (EVA), where ibuprofen was localized within the nonconstant reservoir (EVA core). The model postulated that the drug release through the bulk-degrading PLLA and PLGA layers consisted of two mechanisms: simple diffusional release followed by a degradation-controlled release through a rate-limiting membrane. The proposed model showed very good match with the experimental data of release from microparticles of various layer thicknesses and particle sizes. The underlying drug release mechanisms are dictated by three parameters determined by the model, including constant characteristic of diffusion, end time point of simple diffusion-controlled release and partition coefficient of drug. The presented model is effective for understanding the drug release mechanisms and for the design of this type of dosage form.en_US
dc.relation.ispartofseriesJournal of biomedical materials research part Aen_US
dc.rights© 2012 Wiley Periodicals, Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of biomedical materials research part A, Wiley Periodicals, Inc. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: http://dx.doi.org/10.1002/jbm.a.34292].en_US
dc.titleModeling of drug release from biodegradable triple-layered microparticlesen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.description.versionAccepted version

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