dc.contributor.authorHartono, Yossa Dwi
dc.contributor.authorMun, Yip Yew
dc.contributor.authorZhang, Dawei
dc.date.accessioned2013-11-05T04:34:54Z
dc.date.available2013-11-05T04:34:54Z
dc.date.copyright2013en_US
dc.date.issued2013
dc.identifier.citationHartono, Y. D., Mun, Y. Y., & Zhang, D. (2013). Adsorption and folding dynamics of MPER of HIV-1 gp41 in the presence of dpc micelle. Proteins: Structure, Function, and Bioinformatics, 81(6), 933-944.en_US
dc.identifier.issn0887-3585en_US
dc.identifier.urihttp://hdl.handle.net/10220/17245
dc.description.abstractMembrane-proximal ectodomain region (MPER) of HIV-1 gp41 is known to have several epitopes of monoclonal antibodies. It also plays an important role in the membrane fusion process that is well-evidenced, though not well-elucidated. There are also disputes over the true structure of MPER. In this study, MPER NMR structure in the presence of dodecylphosphatidylcholine micelle is used in the molecular dynamic simulation to elucidate structural dynamics and adsorption to model MPER interaction in a membrane environment. Polarized protein-specific charge derived from its NMR structure is found to better preserve the helical structure found in the NMR structure compared to AMBER03 calculation. The preserved helical structure also adsorb to the micelle using the hydrophobic side-chains, consistent to the NMR structure. Ab initio folding of MPER predicts a structure quite in well agreement with the NMR structure (RMSd 3.9 Å) and shows that the micelle plays a role in the folding process.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesProteins: structure, function, and bioinformaticsen_US
dc.titleAdsorption and folding dynamics of MPER of HIV-1 gp41 in the presence of dpc micelleen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1002/prot.24256


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